ArticleJournal of clinical medicine2019
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course.
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Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.
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106citing papers in PubMed, 3 pooled it
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Who cites it
106 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Associated factors in the development of rapidly progressive interstitial lung disease in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Diagnostic delay of myositis: an integrated systematic review.Orphanet journal of rare diseases · 2022Pooled it
- Defining anti-synthetase syndrome: a systematic literature review.Clinical and experimental rheumatology · 2022Pooled it
- Clinical characteristics of anti-Ro52/TRIM21-positive versus anti-Ro52/TRIM21-negative patients with anti-synthetase syndrome: a retrospective cohort study.Clinical rheumatology · 2026Article
- Article
- Recurrent Ischemic Strokes Caused by HSV-2-Associated Cerebral Vasculitis in Antisynthetase Syndrome.The American journal of case reports · 2026Article
- Emerging therapies in idiopathic inflammatory myopathies.Journal of neuromuscular diseases · 2026Review
- Clinical and Serological Characteristics of Idiopathic Inflammatory Myopathies According to the Presence of Interstitial Lung Disease and Initial Evaluating Medical Specialty: A Single-Center Experience.Journal of personalized medicine · 2026Article
- An Exploratory Analysis of Antibody Dynamics in Isolated Organ Involvement of Antisynthetase Syndrome: A Single-Center Experience.ACR open rheumatology · 2026Article
- The Spectrum of Cutaneous Manifestations in Dermatomyositis: A Comprehensive Review.Journal of clinical medicine · 2026Review
- Advances in Biomarkers and Therapeutic Targets for Idiopathic Inflammatory Myopathies Related Lung Disease.Clinical reviews in allergy & immunology · 2026Review
- Diffuse Alveolar Haemorrhage as a Rare Pulmonary Manifestation of Antisynthetase Syndrome: A Case Series.Journal of clinical medicine · 2026Article
- Hypereosinophilia Associated With Antisynthetase Syndrome With Anti-Ro52/PL12 Co-Positivity: An Unusual Presentation.Clinical case reports · 2026Article
- Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).Journal of internal medicine · 2026Article
- Anti-Ha anti-synthetase syndrome presenting as rapidly progressive interstitial lung disease: a case report of high confidence autoantibody testing.Frontiers in immunology · 2026Article
- Article
- Cluster analysis and risk prediction model construction for antisynthase syndrome-associated interstitial lung disease based on clinical, imaging, and antibody characteristics.Frontiers in medicine · 2026Article
- Case Report: Acute interstitial pneumonia as the initial presentation of Anti-EJ antisynthetase syndrome: a case of severe respiratory failure with rapid response to cyclophosphamide.Frontiers in immunology · 2026Article
- CAR-T and BiTE: new horizons in the treatment of rheumatic autoimmune diseases.Frontiers in immunology · 2026Review
- Unilateral lower limb cellulitis-like edema as an atypical cutaneous manifestation of antisynthetase syndrome: a case report and targeted literature review.Frontiers in medicine · 2026Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
114 authors.
Lorenzo CavagnaDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy.
Ernesto Trallero-AraguásDepartment of Internal Medicine, Vall d'Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, Spain.
Federica MeloniDepartment of Pneumology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN Lung, 27100 Pavia, Italy.
Ilaria CavazzanaDepartment of Rheumatology, University and ASST Spedali Civili-Brescia and ERN ReCONNET, 25123 Brescia, Italy.
Jorge Rojas-SerranoInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico.
Eugen FeistDepartment of Rheumatology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Giovanni ZanframundoDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy.ORCID 0000-0001-5042-1282
Valentina MorandiDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy.
Alain MeyerDepartment of Rheumatology, Hôpitaux Universitaires de Strasbourg and ERN ReCONNET, 67000 Strasbourg, France.
Jose Antonio Pereira da SilvaDepartment of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.ORCID 0000-0002-2782-6780
Carlo Jorge Matos CostaDepartment of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.
Oyvind MolbergDepartment of Rheumatology, Oslo University Hospital, 0372 Oslo, Norway.
Helena AnderssonDepartment of Rheumatology, Oslo University Hospital, 0372 Oslo, Norway.
Veronica CodulloDepartment of Rheumatology, Cochin Hospital, 75014 Paris, France.
Marta MoscaDepartment of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy.
Simone BarsottiDepartment of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy.ORCID 0000-0002-4864-4505
Rossella NeriDepartment of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy.
Carlo ScirèDepartment of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy.
Marcello GovoniDepartment of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy.
Federica FuriniDepartment of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy.
Francisco Javier Lopez-LongoDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Julia Martinez-BarrioDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Udo SchneiderDepartment of Rheumatology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Hanns-Martin LorenzDepartment of Rheumatology, University of Heidelberg, 69117 Heidelberg, Germany.
Andrea DoriaDepartment of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, Italy.
Anna GhirardelloDepartment of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, Italy.
Norberto Ortego-CentenoDepartment of Rheumatology, Hospital Universitario San Cecilio, 18016 Granada, Spain.
Marco ConfalonieriDepartment of Pneumology, University Hospital of Cattinara, 34149 Trieste, Italy.
Paola TomiettoDepartment of Rheumatology, University Hospital of Cattinara, 34149 Trieste, Italy.
Nicolò PipitoneDepartment of Rheumatology, S. Maria Hospital-IRCCS, 42123 Reggio Emilia, Italy.
Ana Belen Rodriguez CambronDepartment of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, Spain.
María Ángeles Blázquez CañameroDepartment of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, Spain.
Reinhard Edmund VollDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.
Sarah WendelDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.
Salvatore ScarpatoDepartment of Rheumatology, Ospedale " Scarlato" Scafati, 84018 Scafati, Italy.
Francois MaurierDepartment of Rheumatology, HP Metz, Hopital Belle-Ile, 57000 Metz, France.
Massimiliano LimontaDepartment of Rheumatology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
Paolo ColombelliDepartment of Rheumatology, Ospedale di Treviglio, 24047 Treviglio, Italy.
Margherita GianniniService de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, France.
Bernard GenyService de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, France.
Eugenio ArrigoniDepartment of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy.
Elena BraviDepartment of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy.
Paola MiglioriniDepartment of Immunology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy.ORCID 0000-0001-6433-4964
Alessandro MathieuDepartment of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, Italy.
Matteo PigaDepartment of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, Italy.ORCID 0000-0002-1126-8315
Ulrich DrottDepartment of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.
Christiane DelbrueckDepartment of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.
Jutta BauhammerDepartment of Rheumatology, ACURA Centre for Rheumatic Diseases, 76530 Baden-Baden, Germany.
Giovanni CagnottoDepartment of Rheumatology, Skane University Hospital, 22242 Lund, Sweden.ORCID 0000-0002-1682-8158
Carlo VancheriDepartment of Pneumology, AOU Catania, 95100 Catania, Italy.
Gianluca SambataroDepartment of Pneumology, AOU Catania, 95100 Catania, Italy.ORCID 0000-0001-9933-1202
Ellen De LangheDepartment of Rheumatology, University Hospitals, 3000 Leuven, Belgium.ORCID 0000-0002-4045-2146
Pier Paolo SainaghiDepartment of Rheumatology at CAAD, DiMet, University of Eastern Piedmont (UPO) and AOU "Maggiore della Carità", 28100 Novara, Italy.ORCID 0000-0001-8322-9158
Cristina MontiDepartment of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, Italy.
Francesca Gigli BerzolariDepartment of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, Italy.
Mariaeva RomanoDepartment of Rheumatology, Niguarda Hospital, 20162 Milan, Italy.
Francesco BonellaDepartment of Pneumology, Ruhrlandklinik, University of Duisburg-Essen and ERN Lung, 45239 Essen, Germany.
Christof SpeckerDepartment of Rheumatology, Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany.
Andreas SchwartingDepartment of Rheumatology, Johannes Gutenberg-University, 55122 Mainz, Germany.
Ignacio Villa BlancoDepartment of Rheumatology, Sierrallana Hospital, 39300 Torrelavega, Spain.
Carlo SelmiDepartment of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Angela CeribelliDepartment of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Laura NunoDepartment of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Antonio Mera-VarelaDepartment of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, Spain.
Nair Perez GomezDepartment of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, Spain.
Enrico FusaroDepartment of Rheumatology, Città della Salute e della Scienza, 10126 Turin, Italy.
Simone ParisiDepartment of Rheumatology, Città della Salute e della Scienza, 10126 Turin, Italy.
Luigi SinigagliaDepartment of Rheumatology, Hospital G. Pini-CTO, 20122 Milan, Italy.
Nicoletta Del PapaDepartment of Rheumatology, Hospital G. Pini-CTO, 20122 Milan, Italy.
Maurizio BenucciDepartment of Rheumatology, Azienda Ospedaliera San Giovanni di Dio, 50143 Firenze, Italy.ORCID 0000-0001-8180-6660
Marco Amedeo CimminoDepartment of Rheumatology, University of Genova 16126 Genova, Italy.
Valeria RiccieriDepartment of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, Italy.
Fabrizio ContiDepartment of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, Italy.
Gian Domenico SebastianiDepartment of Rheumatology, Ospedale San Camillo, 00152 Rome, Italy.ORCID 0000-0003-2969-6649
Annamaria IulianoDepartment of Rheumatology, Ospedale San Camillo, 00152 Rome, Italy.
Giacomo EmmiDepartment of Internal Medicine, AOU Careggi, 50134 Firenze, Italy.
Daniele CammelliDepartment of Immunology, AOU Careggi, 50134 Firenze, Italy.
Marco SebastianiDepartment of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy.
Andreina ManfrediDepartment of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy.
Javier Bachiller-CorralDepartment of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
Walter Alberto Sifuentes GiraldoDepartment of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0003-2548-3988
Giuseppe PaolazziDepartment of Rheumatology, Ospedale Santa Chiara, 38122 Trento, Italy.
Lesley Ann SaketkooUniversity Medical Center- Comprehensive Pulmonary Hypertension Center & Interstitial Lung Disease Clinic Programs, Louisiana State University and Tulane University Schools of Medicine, Pulmonary Division New Orleans, New Orleans, LA 1542, USA.
Roberto GiorgiDepartment of Rheumatology, ASL Cuneo 2, 12051 Alba, Italy.
Fausto SalaffiDepartment of Rheumatology, Polytechnic University of Marche, C. Urbani Hospital, 60035 Jesi, Italy.
Jose CifrianDepartment of Pneumology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain.
Roberto CaporaliDepartment of Clinical Sciences and Community Health, University of Milan and Gaetano Pini Hospital, 20122 Milan, Italy.
Francesco LocatelliDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy.
Enrico MarchioniDepartment of Neurology, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Alberto PesciDepartment of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy.
Giulia DeiDepartment of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy.
Maria Rosa PozziDepartment of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy.
Lomater ClaudiaDepartment of Rheumatology, Mauriziano Hospital, 10126 Turin, Italy.
Jorg DistlerDepartment of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Johannes KnitzaDepartment of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.ORCID 0000-0001-9695-0657
George SchettDepartment of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Florenzo IannoneRheumatology Unit-DETO, University of Bari, 70121 Bari, Italy.
Marco FornaroRheumatology Unit-DETO, University of Bari, 70121 Bari, Italy.ORCID 0000-0003-1716-7432
Franco FranceschiniDepartment of Rheumatology, University and ASST Spedali Civili-Brescia and ERN ReCONNET, 25123 Brescia, Italy.
Luca QuartuccioClinic of Rheumatology, Department of Medicine, Santa Maria della Misericordia Hospital and University of Udine, 33100 Udine, Italy.
Roberto GerliRheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, Italy.
Elena BartoloniRheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, Italy.ORCID 0000-0003-4776-2136
Silvia Bellando RandoneDepartment of Rheumatology, AOU Careggi, 50134 Firenze, Italy.
Giuseppe ZampognaDepartment of Rheumatology, AO Brunico, 39031 Bruneck, Italy.
Montserrat I Gonzalez PerezInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico.
Mayra MejiaInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico.
Esther VicenteDepartment of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, Spain.
Konstantinos TriantafylliasDepartment of Rheumatology, ACURA Center for Rheumatic Diseases, 55543 Bad Kreuznach, Germany.
Raquel Lopez-MejiasDepartment of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain.
Marco Matucci-CerinicDepartment of Rheumatology, AOU Careggi, 50134 Firenze, Italy.
Albert Selva-O'CallaghanDepartment of Internal Medicine, Vall d'Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, Spain.
Santos CastañedaDepartment of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, Spain.
Carlomaurizio MontecuccoDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy.
Miguel Angel Gonzalez-GayDepartment of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain.ORCID 0000-0002-7924-7406
Funding
FOREUM - Foundation for Research in Rheumatology http://www.foreum.org/prg_13_myositis_transition.cfm
Abstract
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.
Indexed as
antisynthetase antibodiesantisynthetase syndromearthritisinterstitial lung diseasemyositis
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