ArticleInternational journal of environmental research and public health2019
Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Systematic Review and Meta-Analysis on Heavy Metals and Trace Elements in Mild Cognitive Impairment.Biological trace element research · 2026Pooled it
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- A data-driven high-accuracy modelling of acidity behavior in heavily contaminated mining environments.Scientific reports · 2025Article
- A Heavy Metal Ion Water Quality Detection Model Based on Spectral Analysis: New Methods for Enhancing Detection Speed and Visible Spectral Denoising.Sensors (Basel, Switzerland) · 2025Article
- Review
- Synthesis of a nitrogen-rich dendrimer grafted on magnetic nanoparticles for efficient removal of Pb(ii) and Cd(ii) ions.RSC advances · 2024Article
- Serum calcium and magnesium levels and quality of life in environmentally exposed populations in Kazakhstan.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Heavy metal contamination in Sungai Petani, Malaysia: a wastewater-based epidemiology study.Journal of water and health · 2024Article
- Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities.BMC molecular and cell biology · 2023Observational
- Hair Zinc and Chromium Levels Were Associated with a Reduced Likelihood of Age Related Cognitive Decline in Centenarians and Oldest-Old Adults.The journal of nutrition, health & aging · 2023Article
- Person identification using the composition of elements in human hair.Journal of medicine and life · 2022Article
- Facets of ICP-MS and their potential in the medical sciences-Part 1: fundamentals, stand-alone and hyphenated techniques.Analytical and bioanalytical chemistry · 2022Review
- Sample preparation method for metal(loid) contaminant quantitation in rodent hair collected in Yuma County, Arizona.Environmental monitoring and assessment · 2021Article
- Identification Framework of Contaminant Spill in Rivers Using Machine Learning with Breakthrough Curve Analysis.International journal of environmental research and public health · 2021Article
- Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort.International journal of environmental research and public health · 2020Article
- Systematic Assessment of Health Risk from Metals in Surface Sediment of the Xiangjiang River, China.International journal of environmental research and public health · 2020Article
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13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, trace elements (TE) levels were evaluated in scalp hair along the continuum from healthy subjects (HS) to patients suffering from subjective memory concerns (SMC), and/or mild cognitive impairment (MCI), and those with already installed dementia (DEM) in order to: (i) assess the effects of environmental and lifestyle factors on TE concentrations and (ii) evaluate the analyzed elements as possible diagnostic biomarkers for the disease. The study involved 79 mainly permanent residents, >55 years old, from the city of Estarreja (northern Portugal), a former industrial area. The health status of the participants was assessed by means of a complete socio-demographic questionnaire and through cognitive screening tests, namely the Mini-Mental State Examination (MMSE). The test scores were categorized and used in the statistical analysis. Hair samples were collected and analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) ICP-MS for selected TE. Dementia appears to be associated with higher age, the female gender, lower education level, and longer residence time in the study area. In addition, most of the participants diagnosed with dementia frequently consume home-grown foodstuffs, some irrigated with contaminated well water. The calculation of the TE enrichment factors of soil samples collected in kitchen gardens/small farms in the vicinity of the Estarreja Chemical Complex (ECC) reinforces the degree of Hg soil contamination in the area, due to anthropogenic sources that can be a source for the population Hg exposure route among others. Mercury levels in hair differed significantly between the four individual groups (HS, SMC, MCI, and DEM), increasing from healthy to dementia participants. Improved diagnostic results can be obtained using hair TE signatures coupled with MMSE scores. This strategy may prove useful for predictive diagnosis in population screening for cognitive impairment.
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