Evidence map›Paper›PMID 31752095›Full record

ReviewNutrients2019

Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions.

Maria Vittoria Ristori, Andrea Quagliariello, Sofia Reddel, Gianluca Ianiro, Stefano Vicari, Antonio Gasbarrini, Lorenza Putignani

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 6 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 6 syntheses or guidelines pooled it, 203 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Supplementation with abioRxiv : the preprint server for biology · 2025
    Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria Vittoria RistoriUnit of Human Microbiome, Children's Hospital and Research Institute "Bambino Gesù", IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.
Andrea QuagliarielloUnit of Human Microbiome, Children's Hospital and Research Institute "Bambino Gesù", IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.ORCID 0000-0002-3941-3684
Sofia ReddelUnit of Human Microbiome, Children's Hospital and Research Institute "Bambino Gesù", IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.
Gianluca IaniroDipartimento di Gastroenterologia, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Stefano VicariNeuropsichiatria dell'infanzia e dell'adolescenza, Children's Hospital and Research Institute "Bambino Gesù", IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.
Antonio GasbarriniIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Lorenza PutignaniUnits of Parasitology and Human Microbiome, Children's Hospital and Research Institute "Bambino Gesù", IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.ORCID 0000-0003-0134-2830
Bambino Gesù Children's Hospital · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex behavioral syndrome that is characterized by speech and language disorders, intellectual impairment, learning and motor dysfunctions. Several genetic and environmental factors are suspected to affect the ASD phenotype including air pollution, exposure to pesticides, maternal infections, inflammatory conditions, dietary factors or consumption of antibiotics during pregnancy. Many children with ASD shows abnormalities in gastrointestinal (GI) physiology, including increased intestinal permeability, overall microbiota alterations, and gut infection. Moreover, they are "picky eaters" and the existence of specific sensory patterns in ASD patients could represent one of the main aspects in hampering feeding. GI disorders are associated with an altered composition of the gut microbiota. Gut microbiome is able to communicate with brain activities through microbiota-derived signaling molecules, immune mediators, gut hormones as well as vagal and spinal afferent neurons. Since the diet induces changes in the intestinal microbiota and in the production of molecules, such as the SCFA, we wanted to investigate the role that nutritional intervention can have on GI microbiota composition and thus on its influence on behavior, GI symptoms and microbiota composition and report which are the beneficial effect on ASD conditions.

Indexed as

Child Nutritional Physiological PhenomenaGastrointestinal MicrobiomeAutism Spectrum DisorderChildChild, PreschoolDietFatty Acids, VolatileFood PreferencesGastrointestinal DiseasesHumansNeurotransmitter AgentsNutritional StatusSerotoninFatty Acids, VolatileNeurotransmitter AgentsSerotoninanthropometryautism spectrum disorders (ASD)dietgastrointestinal symptomsgut microbiomemetabolitesnutritional status

Identifiers

PMID31752095
PMCPMC6893818
OpenAlexW2985368039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.