Evidence map›Paper›PMID 31752055›Full record

ArticleJournal of microbiology and biotechnology2020

Salvianolic Acid B Inhibits Hand-Foot-Mouth Disease Enterovirus 71 Replication through Enhancement of AKT Signaling Pathway.

So-Hee Kim, Jihye Lee, Ye Lin Jung, Aerum Hong, Sang-Jip Nam, Byung-Kwan Lim

Open access · bronzeAbstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Advances in anti-EV-A71 drug development research.Journal of advanced research · 2024
    Review
  7. Review
  8. Article
  9. Inhibitory Effect ofMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

So-Hee KimDepartment of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk 28024, Republic of Korea.
Jihye LeeDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 120-750, Republic of Korea.
Ye Lin JungDepartment of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk 28024, Republic of Korea.
Aerum HongGraduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea.
Sang-Jip NamDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 120-750, Republic of Korea.
Byung-Kwan LimDepartment of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk 28024, Republic of Korea.
Ewha Womans University · KRJungwon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the

Indexed as

AnimalsAntiviral AgentsBenzofuransChlorocebus aethiopsDepsidesEnterovirus A, HumanHand, Foot and Mouth DiseaseHeLa CellsHumansPlant ExtractsProto-Oncogene Proteins c-aktSalvia miltiorrhizaSignal TransductionVero CellsVirus ReplicationAntiviral AgentsBenzofuransDepsidesPlant ExtractsProto-Oncogene Proteins c-aktsalvianolic acid Bapoptosisenterovirus71hand-foot-mouth diseasemyocarditisSalvianolic acid B

Identifiers

PMID31752055
PMCPMC9728356
OpenAlexW2991059420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.