Evidence map›Paper›PMID 31751908›Full record

Trial reportSleep medicine2020

Impact of sleep opportunity on asthma outcomes in adolescents.

Lisa J Meltzer, Dean W Beebe, Stephanie Jump, Kassie Flewelling, D Sundström, Michael White, Pamela L Zeitlin, Matthew J Strand

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Sleep medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Predictive correlates of poor sleep associated with increased risk of severe asthma exacerbations among children with moderate-to-severe asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Association between Asthma and Oral Health Symptoms in Adolescents.International journal of environmental research and public health · 2023
    Article
  10. Article
  11. The relationship between teen-reported nocturnal asthma symptoms and daily functioning.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022
    Article
  12. Effects of daily peer problems on sleep and the severity of pediatric asthma symptoms.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022
    Article
  13. Review
  14. Article
  15. Association between Non-Restorative Sleep and Quality of Life in Chinese Adolescents.International journal of environmental research and public health · 2020
    Article
  16. Associations of sleep duration with patient-reported outcomes and health care use in US adults with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lisa J MeltzerDepartment of Pediatrics, National Jewish Health, USA. Electronic address: meltzerL@njhealth.org.
Dean W BeebeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, USA.
Stephanie JumpDepartment of Pediatrics, National Jewish Health, USA.
Kassie FlewellingDepartment of Psychology, University of Colorado Denver, USA.
D SundströmDepartment of Pediatrics, National Jewish Health, USA.
Michael WhiteDepartment of Pediatrics, National Jewish Health, USA.
Pamela L ZeitlinDepartment of Pediatrics, National Jewish Health, USA.
Matthew J StrandDivision of Biostatistics, National Jewish Health, USA.
University of Colorado Denver · USNational Jewish Health · USUniversity of Cincinnati · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Deficient Sleep Lung Function, and Functional Outcomes in Adolescents with AsthmaR01HL119441 · NHLBI · NATIONAL JEWISH HEALTH · PI MELTZER, LISA J · 2015 to 2018
$1.5M
NCRR NIH HHS UL1 RR025780NHLBI NIH HHS R01 HL119441
6 · The paper itself

Abstract

rationaleInsufficient sleep is associated with a number of negative health outcomes; as most adolescents obtain <7 h of sleep per night, it is important to understand how sleep impacts asthma among adolescents.

objectivesTo examine the impact of sleep opportunity on asthma in adolescents.

methodsIn this study, 54 adolescents with asthma (12-17 years, 69% female, 65% Caucasian) participated in a randomized, cross-over sleep manipulation trial, including a sleep stabilization week, five nights of a "Short" sleep opportunity (time in bed: 6.5 h/night), and five nights of a "Long" sleep opportunity (time in bed: 9.5 h/night). Wake times were consistent across all three study weeks. Primary outcomes were lung function (daily peak expiratory flow rate, weekly spirometry) and functional asthma outcomes (daily asthma symptoms, Asthma Control Questionnaire, PROMIS Asthma Impact Scale). Markers of inflammation were also explored. MEASUREMENTS AND MAIN

resultsCompared to the Long sleep week, during the Short sleep week, morning FEV1 was lower (p = 0.006), while asthma symptoms and albuterol use was higher (p < 0.05), and asthma showed a trend towards greater negative impact on daily life (p = 0.07). No differences were found for weekly measures of lung function or inflammation.

conclusionsAn insufficient sleep opportunity negatively impacts objective and subjective daily symptoms of asthma in adolescents, as well as health related quality of life. As most adolescents are significantly sleep deprived, it is important to target sleep health in the treatment of asthma.

Indexed as

AdolescentAlbuterolAsthmaChildCross-Over StudiesFemaleHumansMaleQuality of LifeSleepSpirometryAlbuterolAdolescencePediatricsQuality of lifeSleep extensionSleep restriction

Identifiers

PMID31751908
PMCPMC9354610
OpenAlexW2963967452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.