ArticleDevelopmental cognitive neuroscience2019
Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.
Article in Developmental cognitive neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Longitudinal Central Adiposity Accumulation is Associated with Cortical Alteration and Impaired Cognitive Function in Adolescents.medRxiv : the preprint server for health sciences · 2026Article
- Bias in Structural MRI Correlates of Delay Discounting due to Head Motion.Human brain mapping · 2026Article
- Predicting developmental norms from baseline cortical thickness in longitudinal studies.Biology of sex differences · 2026Article
- Central Obesity Disrupts Brain Network Organization in Aging via Metabolic and Structural Pathways.Aging and disease · 2025Article
- Exploring the interplay between circadian rhythms and obesity: A Boolean network approach to understanding metabolic dysregulation.PloS one · 2025Article
- Relationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study.Nature. Mental health · 2025Article
- Neural correlates of obesity across the lifespan.Communications biology · 2024Article
- Hypothalamic volume is associated with body mass index.NeuroImage. Clinical · 2023Article
- The Developing Brain: Considering the Multifactorial Effects of Obesity, Physical Activity & Mental Wellbeing in Childhood and Adolescence.Children (Basel, Switzerland) · 2022Review
- Differential Effects of Fundamental and Longitudinal Life History Trade-Offs on Delay Discounting: An Evolutionary Framework.Behavioral sciences (Basel, Switzerland) · 2022Article
- Relationship between impulsivity, uncontrolled eating and body mass index: a hierarchical model.International journal of obesity (2005) · 2022Article
- Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation.Frontiers in neuroscience · 2022Review
- Obesity and Gray Matter Volume Assessed by Neuroimaging: A Systematic Review.Brain sciences · 2021Review
- Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood.International journal of obesity (2005) · 2020Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Overweight and obesity are associated with functional and structural alterations in the brain, but how these associations change across critical developmental periods remains unknown. Here, we examined the relationship between age, body mass index (BMI) and cortical thickness (CT) in healthy adolescents (n = 70; 14-19 y) and adults (n = 75; 25-45 y). We also examined the relationship between adiposity, impulsivity, measured by delay discounting (DD), and CT of the inferior frontal gyrus (IFG), a region key to impulse control. A significant age-by-BMI interaction was observed in both adolescents and adults; however, the direction of this relationship differed between age groups. In adolescents, increased age-adjusted BMI Z-score attenuated age-related CT reductions globally and in frontal, temporal and occipital regions. In adults, increased BMI augmented age-related CT reductions, both globally and in bilateral parietal cortex. Although DD was unrelated to adiposity in both groups, increased DD and adiposity were both associated with reduced IFG thickness in adolescents and adults. Our findings suggest that the known age effects on CT in adolescence and adulthood are moderated by adiposity. The association between weight, cortical development and its functional implications would suggest that future studies of adolescent and adult brain development take adiposity into account.
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