ArticleNeuroImage2020
Morphometric development of the human fetal cerebellum during the early second trimester.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fetal brain MRI atlases and datasets: A review.NeuroImage · 2024Pooled it
- Super-resolution MRI-derived brainstem and cerebellar volumes in fetuses between 22 weeks and 32 weeks of gestation.Pediatric radiology · 2026Article
- Normal growth, sexual dimorphism, and lateral asymmetry of the fetal posterior fossa during the late second and third trimesters.Pediatric radiology · 2026Article
- The early alteration of brainstem and cerebellum, and their relationship with cerebral cortex: anQuantitative imaging in medicine and surgery · 2025Article
- The potential ameliorative effect of mesenchymal stem cells-derived exosomes on cerebellar histopathology and their modifying role on PI3k-mTOR signaling in rat model of autism spectrum disorder.Journal of molecular histology · 2025Article
- Structural deviations of the posterior fossa and the cerebellum and their cognitive links in a neurodevelopmental deletion syndrome.Molecular psychiatry · 2024Article
- Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age.Cerebellum (London, England) · 2024Article
- Aging pattern of the brainstem based on volumetric measurement and optimized surface shape analysis.Brain imaging and behavior · 2024Article
- Morphological changes in the cerebellum during aging: evidence from convolutional neural networks and shape analysis.Frontiers in aging neuroscience · 2024Article
- Fetal Brain Growth in the Early Second Trimester.AJNR. American journal of neuroradiology · 2023Observational
- Assessment of longitudinal brain development using super-resolution magnetic resonance imaging following fetal surgery for open spina bifida.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Article
- Neuromorphological Atlas of Human Prenatal Brain Development: White Paper.Life (Basel, Switzerland) · 2023Article
- Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study.Neuroradiology · 2021Article
- Alterations of brain metrics in fetuses of women with polycystic ovary syndrome : a retrospective study based on fetal magnetic resonance imaging.BMC pregnancy and childbirth · 2021Article
- Second-Trimester Placental and Thyroid Hormones Are Associated With Cognitive Development From Ages 1 to 3 Years.Journal of the Endocrine Society · 2021Article
- Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals.Frontiers in neuroscience · 2021Article
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Authors and funding
12 authors.
Funding
Abstract
The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal cerebellum using 7.0-T high-resolution MR images obtained in 35 specimens with gestational ages ranging from 15 to 22 weeks. Volume measurements and shape analysis were performed to quantitatively evaluate global and regional cerebellar growth. The absolute volume of the fetal cerebellum showed a quadratic growth with increasing gestational age, while the pattern of relative volume changes revealed that the cerebellum grew at a greater pace than the cerebrum after 17 gestational weeks. Shape analysis was used to examine the distinctive development of subregions of the cerebellum. The extreme lateral portions of both cerebellar hemispheres showed the lowest rate of growth. The anterior lobe grew faster than most of the posterior lobe. These findings expand our understanding of the early growth pattern of the human cerebellum and could be further used to assess the developmental conditions of the fetal brain.
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