ArticlePloS one2019
Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Interpregnancy Weight Change and Adverse Birth Outcomes: Cohort Study Using Brazil's Routine Register-Based Linked Data.Maternal & child nutrition · 2025Article
- Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization.International journal of women's health · 2024Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe relationship between maternal weight change between pregnancies and premature birth is unclear. This study aimed to investigate whether interpregnancy weight change between first and second, or second and third pregnancy is associated with premature birth.
methodsRoutinely collected data from 2003 to 2018 from one English maternity centre was used to produce two cohorts. The primary cohort (n = 14,961 women) consisted of first and second live-birth pregnancies. The secondary cohort (n = 5,108 women) consisted of second and third live-birth pregnancies. Logistic regression models were used to examine associations between interpregnancy BMI change and premature births adjusted for confounders. Subgroup analyses were carried out, stratifying by initial pregnancy BMI groups and analysing spontaneous and indicated premature births separately.
resultsIn the primary cohort, 3.4% (n = 514) of births were premature compared to 4.2% (n = 212) in the secondary cohort, with fewer indicated than spontaneous premature births in both cohorts. PRIMARY COHORT: Weight loss (>3kg/m2) was associated with increased odds of premature birth (adjusted odds ratio (aOR):3.50, 95% CI: 1.78-6.88), and spontaneous premature birth (aOR: 3.34, 95%CI: 1.60-6.98), in women who were normal weight (BMI 18.5-25kg/m2) at first pregnancy. Weight gain >1kg/m2 was not associated with premature birth regardless of starting BMI. SECONDARY COHORT: Losing >3kg/m2 was associated with increased odds of premature birth (aOR: 2.01, 95%CI: 1.05-3.87), when analysing the whole sample, but not when restricting the analysis to women who were overweight or obese at second pregnancy.
conclusionsNormal-weight women who lose significant weight (>3kg/m2) between their first and second live pregnancies have greater odds of premature birth compared to normal-weight women who remain weight stable in the interpregnancy period. There was no evidence of association between weight change in women who were overweight or obese at the start of their first pregnancy and premature birth.
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