ArticlePloS one2019
Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- How gliomas affect white matter tract bundles associated with the limbic cortex.Neuroimage. Reports · 2025Article
- Qualitative and Visual Along-Tract Analysis of Diffusion-Based Parameters in Patients with Diffuse Gliomas.Brain sciences · 2024Article
- Network analysis shows decreased ipsilesional structural connectivity in glioma patients.Communications biology · 2022Article
- Machine learning-based prediction of motor status in glioma patients using diffusion MRI metrics along the corticospinal tract.Brain communications · 2022Article
- Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning.BMC medicine · 2021Article
- In vivo restricted diffusion imaging (RDI) is sensitive to differences in axonal density in typical children and adults.Brain structure & function · 2021Article
- From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures.Frontiers in neurology · 2021Article
- Risk Assessment by Pre-surgical Tractography in Left Hemisphere Low-Grade Gliomas.Frontiers in neurology · 2021Article
- Acute changes in diffusion tensor-derived metrics and its correlation with the motor outcome in gliomas adjacent to the corticospinal tract.Surgical neurology international · 2021Article
- Retrospective analysis of hemispheric structural network change as a function of location and size of glioma.Brain communications · 2021Article
- The Ethical Dilemma in the Surgical Management of Low Grade Gliomas According to the Variable Availability of Resources and Surgeon Experience.Asian journal of neurosurgeryReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Gliomas account for 26.5% of all primary central nervous system tumors. Recent studies have used diffusion tensor imaging (DTI) to extract white matter fibers and the diffusion coefficients derived from MR processing to provide useful, non-invasive insights into the extent of tumor invasion, axonal integrity, and gross differentiation of glioma from metastasis. Here, we extend this work by examining whether a tract-based analysis can improve non-invasive localization of tumor impact on white matter integrity. This study retrospectively analyzed preoperative magnetic resonance sequences highlighting contrast enhancement and DTI scans of 13 subjects that were biopsy-confirmed to have either high or low-grade glioma. We reconstructed the corticospinal tract and superior longitudinal fasciculus by applying atlas-based regions of interest to fibers derived from whole-brain deterministic streamline tractography. Within-subject comparison of hemispheric diffusion coefficients (e.g., fractional anisotropy and mean diffusivity) indicated higher levels of white matter degradation in the ipsilesional hemisphere. Novel application of along-tract analyses revealed that tracts traversing the tumor region showed significant white matter degradation compared to the contralesional hemisphere and ipsilesional tracts displaced by the tumor.
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Registered trials
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