ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020
Peripheral microvascular serotoninergic signaling is dysregulated in young adults with major depressive disorder.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Salsalate negatively impacts microvascular function in women with endometriosis.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Reflex vasodilation and sweating in response to passive whole body heating are blunted in women with major depressive disorder.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Frontiers in cellular neuroscience · 2026Review
- Comparative Evaluation of Antidepressant and Anxiolytic Effects of Escitalopram, Crocin, and their Combination in Rats.Advanced biomedical research · 2024Article
- Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview.Frontiers in pharmacology · 2023Review
- Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder.American journal of physiology. Heart and circulatory physiology · 2022Article
- Microvascular β-Adrenergic Receptor-Mediated Vasodilation Is Attenuated in Adults With Major Depressive Disorder.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Cerebrovascular reactivity is blunted in young adults with major depressive disorder: The influence of current depressive symptomology.Journal of affective disorders · 2021Article
- Sensory nerve-mediated and nitric oxide-dependent cutaneous vasodilation in normotensive and prehypertensive non-Hispanic blacks and whites.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Dysfunction of the brain serotonergic system is implicated in the pathogenesis of major depressive disorder (MDD). Serotonin is also a vasoactive signaling molecule, the effects of which are modulated by both nitric oxide (NO) and the serotonin transporter [the primary target of selective serotonin reuptake inhibitors (SSRIs)]. Despite its role in the neurobiology of depression, serotoninergic signaling mechanisms in the microvasculature of adults with MDD are unknown. We hypothesized that
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.