Evidence map›Paper›PMID 31750926›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2020

Protecting patient privacy in survival analyses.

Luca Bonomi, Xiaoqian Jiang, Lucila Ohno-Machado

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Private Continuous Survival Analysis with Distributed Multi-Site Data.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2023
    Article
  8. Article
  9. Mitigating Membership Inference in Deep Survival Analyses with Differential Privacy.Proceedings. IEEE International Conference on Healthcare Informatics · 2023
    Article
  10. Sharing personal ECG time-series data privately.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  11. Sharing Time-to-Event Data with Privacy Protection.Proceedings. IEEE International Conference on Healthcare Informatics · 2022
    Article
  12. Article
  13. Differential privacy in health research: A scoping review.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luca BonomiDepartment of Biomedical Informatics, UC San Diego Health, University of California, San Diego, La Jolla, California, USA.
Xiaoqian JiangSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Lucila Ohno-MachadoDepartment of Biomedical Informatics, UC San Diego Health, University of California, San Diego, La Jolla, California, USA.

Funding

Protecting Privacy and Facilitating Shared Access of Clinical and Genetic Data of Special PopulationsR01HL136835 · NHLBI · YALE UNIVERSITY · PI OHNO-MACHADO, LUCILA · 2018 to 2022
$6.5M
Decentralized differentially-private methods for dynamic data release and analysisR01GM118609 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN, OHNO-MACHADO, LUCILA · 2017 to 2020
$2.3M
SAFEGENOMES: Strong privacy Assurance For Effective GENOME SharingK99HG010493 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONOMI, LUCA · 2019 to 2020
$222k
NHGRI NIH HHS K99 HG010493NHLBI NIH HHS R01 HL136835NIGMS NIH HHS R01 GM118609
6 · The paper itself

Abstract

objectiveSurvival analysis is the cornerstone of many healthcare applications in which the "survival" probability (eg, time free from a certain disease, time to death) of a group of patients is computed to guide clinical decisions. It is widely used in biomedical research and healthcare applications. However, frequent sharing of exact survival curves may reveal information about the individual patients, as an adversary may infer the presence of a person of interest as a participant of a study or of a particular group. Therefore, it is imperative to develop methods to protect patient privacy in survival analysis. MATERIALS AND

methodsWe develop a framework based on the formal model of differential privacy, which provides provable privacy protection against a knowledgeable adversary. We show the performance of privacy-protecting solutions for the widely used Kaplan-Meier nonparametric survival model.

resultsWe empirically evaluated the usefulness of our privacy-protecting framework and the reduced privacy risk for a popular epidemiology dataset and a synthetic dataset. Results show that our methods significantly reduce the privacy risk when compared with their nonprivate counterparts, while retaining the utility of the survival curves. DISCUSSION: The proposed framework demonstrates the feasibility of conducting privacy-protecting survival analyses. We discuss future research directions to further enhance the usefulness of our proposed solutions in biomedical research applications.

conclusionThe results suggest that our proposed privacy-protection methods provide strong privacy protections while preserving the usefulness of survival analyses.

Indexed as

ConfidentialityKaplan-Meier EstimateSurvival AnalysisHumansPrivacyactuarialdata privacydata sharingKaplan-Meiersurvival analysis

Identifiers

PMID31750926
PMCPMC7025359

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.