ArticlePlant & cell physiology2020
Nickel Toxicity Targets Cell Wall-Related Processes and PIN2-Mediated Auxin Transport to Inhibit Root Elongation and Gravitropic Responses in Arabidopsis.
Article in Plant & cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 90 citations in OpenAlex.
- Nickel Toxicity in Plants.International journal of molecular sciences · 2026Review
- Bio-effects of engineering nanomaterials NiFe-based LDHs on ryegrass-soil system.Advanced biotechnology · 2026Article
- The Critical Concentration of Nickel Sufficient for Growth and Nutrient Accumulation of Newhall Navel Orange.Plants (Basel, Switzerland) · 2026Article
- Ramalina farinacea mitigates cytogenotoxicity and physiological, biochemical, and anatomical alterations induced by nickel in Allium cepa.Scientific reports · 2025Article
- Physiological and molecular bases of the nickel toxicity responses in tomato.Stress biology · 2024Article
- Decrypting Molecular Mechanisms Involved in Counteracting Copper and Nickel Toxicity in Jack Pine (Plants (Basel, Switzerland) · 2024Article
- Article
- Proline-mediated redox regulation in wheat for mitigating nickel-induced stress and soil decontamination.Scientific reports · 2024Article
- Role of transcriptional regulation in auxin-mediated response to abiotic stresses.Frontiers in genetics · 2024Review
- Design and Synthesis of Poly(2,2'-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation with Biorelevant Metal Cations.Inorganic chemistry · 2023Article
- Transcriptome Analysis Reveals Changes in Whole Gene Expression, Biological Process, and Molecular Functions Induced by Nickel in Jack Pine (Plants (Basel, Switzerland) · 2023Article
- The TabHLH094-TaMYC8 complex mediates the cadmium response in wheat.Molecular breeding : new strategies in plant improvement · 2023Article
- Arbuscular mycorrhiza mitigates zinc stress onFrontiers in plant science · 2022Article
- Physiological, photochemical, and antioxidant responses of wild and cultivated Carthamus species exposed to nickel toxicity and evaluation of their usage potential in phytoremediation.Environmental science and pollution research international · 2022Article
- Quantitative trait loci mapping reveals important genomic regions controlling root architecture and shoot biomass under nitrogen, phosphorus, and potassium stress in rapeseed (Frontiers in plant science · 2022Article
- The thiol-reductase activity of YUCCA6 enhances nickel heavy metal stress tolerance in Arabidopsis.Frontiers in plant science · 2022Article
- Article
- Transcriptomic Characterization of the Effects of Selenium on Maize Seedling Growth.Frontiers in plant science · 2021Article
- Role ofPlant direct · 2020Article
- All Roads Lead to Auxin: Post-translational Regulation of Auxin Transport by Multiple Hormonal Pathways.Plant communications · 2020Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contamination of soils with heavy metals, such as nickel (Ni), is a major environmental concern due to increasing pollution from industrial activities, burning of fossil fuels, incorrect disposal of sewage sludge, excessive manure application and the use of fertilizers and pesticides in agriculture. Excess Ni induces leaf chlorosis and inhibits plant growth, but the mechanisms underlying growth inhibition remain largely unknown. A detailed analysis of root development in Arabidopsis thaliana in the presence of Ni revealed that this heavy metal induces gravitropic defects and locally inhibits root growth by suppressing cell elongation without significantly disrupting the integrity of the stem cell niche. The analysis of auxin-responsive reporters revealed that excess Ni inhibits shootward auxin distribution. Furthermore, we found that PIN2 is very sensitive to Ni, as the presence of this heavy metal rapidly reduced PIN2 levels in roots. A transcriptome analysis also showed that Ni affects the expression of many genes associated with plant cell walls and that Ni-induced transcriptional changes are largely independent of iron (Fe). In addition, we raised evidence that excess Ni increases the accumulation of reactive oxygen species and disturbs the integrity and orientation of microtubules. Together, our results highlight which processes are primarily targeted by Ni to alter root growth and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.