ArticleBioMedicine2019
Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice.
Article in BioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Review
- The Chronic and Acute Toxicity of Traditional Medicines ContainingJournal of pharmacopuncture · 2023Article
- Chemical Profiling and Therapeutic Evaluation of Standardized Hydroalcoholic Extracts ofMolecules (Basel, Switzerland) · 2023Article
- Safety of the Oral Triphala Recipe from Acute and Chronic Toxicity Tests in Sprague-Dawley Rats.Toxics · 2022Article
- Improved up-and-down procedure for acute toxicity measurement with reliable LDBMC pharmacology & toxicology · 2022Article
- Anti-Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model.
methodsIn both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.
resultsIn the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) of Achillea wilhelmsii extract was determined ≥5000 mg/kg and that of Terminalia chebula extract 2754.436 (2438-3114) mg/kg. The highest dose of T. chebula extract induced few histopathological changes.
conclusionIt will be useful to gain information on the minimum lethal doses of T. chebula and A. wilhelmsii to adopt safe doses of the two plants.
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Registered trials
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