ArticleAnnals of clinical and translational neurology2019
High-frequency oscillations mirror severity of human temporal lobe seizures.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Epigenetic histone deacetylase inhibition by sodium butyrate reduces neuroinflammation, improves neurological dysfunction and promotes disease modification of epileptogenesis following traumatic brain injury.Experimental neurology · 2026Article
- Unlocking Insights from Postictal EEGs: Investigating Predictive Markers of Seizure Recurrence.Annals of biomedical engineering · 2026Article
- Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.Annals of clinical and translational neurology · 2024Article
- Connectivity of high-frequency bursts as SOZ localization biomarker.Frontiers in network physiology · 2024Article
- Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.Brain : a journal of neurology · 2023Article
- Drug-resistant epilepsy and the hypothesis of intrinsic severity: What about the high-frequency oscillations?Epilepsia open · 2022Review
- Distinction of Physiologic and Epileptic Ripples: An Electrical Stimulation Study.Brain sciences · 2021Article
- Ictal Occurrence of High-Frequency Oscillations Correlates With Seizure Severity in a Rat Model of Temporal Lobe Epilepsy.Frontiers in human neuroscience · 2021Article
- Interictal Fast Ripples Are Associated With the Seizure-Generating Lesion in Patients With Dual Pathology.Frontiers in neurology · 2020Article
- HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy.Epilepsy currentsArticle
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Authors and funding
6 authors.
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Abstract
objectiveMany patients with epilepsy have both focal and bilateral tonic-clonic seizures (BTCSs), but it is largely unclear why ictal activity spreads only sometimes. Previous work indicates that interictal high-frequency oscillations (HFOs), traditionally subdivided into ripples (80-250 Hz) and fast ripples (250-500 Hz), are a promising biomarker of epileptogenicity. We aimed to investigate whether HFOs correlate with the emergence of seizure activity and whether they differ between focal seizures (FSs) with impaired awareness and BTCSs.
methodsWe retrospectively analyzed 15 FSs and 13 BTCSs from seven patients with mesial temporal lobe epilepsy, each of them with at least one BTCS and at least one FS. Representative intervals of intracranial electroencephalography from the seizure onset zone (SOZ) and remote non-SOZ areas were selected to compare pre-ictal, complex focal, tonic-clonic, and postictal periods. Ripples and fast ripples were visually identified and their density, that is, percentage of time occupied by the respective events, computed.
resultsRipple and fast ripple densities increased inside the SOZ after seizure onset (P < 0.01) and in remote areas after progression to BTCSs (P < 0.01). Postictal SOZ ripple density dropped below pre-ictal levels (P < 0.001). Prior to onset of bilateral tonic-clonic movements, ripple density inside the SOZ is higher in BTCSs than in FSs (P < 0.05).
interpretationRipples and fast ripples correlate with onset and spread of ictal activity. Abundant ripples inside the SOZ may reflect the activation of specific neuronal networks related to imminent spread of seizure activity.
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