ArticleMolecular genetics & genomic medicine2020
The SNP rs4846048 of MTHFR enhances the cervical cancer risk through association with miR-522: A preliminary report.
Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Interaction ofOpen life sciences · 2025Article
- Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring.BMC cardiovascular disorders · 2021Article
- Targeting of ΔNp63α by miR-522 promotes the migration of breast epithelial cells.FEBS open bio · 2021Article
- A Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma.Pharmacogenomics and personalized medicine · 2021Article
- Associations of theBiomedical reports · 2021Article
- The SNP rs4846048 of MTHFR enhances the cervical cancer risk through association with miR-522: A preliminary report.Molecular genetics & genomic medicine · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present research was designed to explore the association between single nucleotide polymorphisms (SNPs) at the 3'-untranslated region (3'-UTR) of methylenetetrahydrofolate reductase (MTHFR) and the risk of cervical cancer (CC).
methodsFrom May 2015 to October 2016, a total of 197 patients (diagnosed with CC and precancerous lesions, and underwent surgical treatments) were enrolled in the study. Meanwhile, a total of 80 healthy cases were used as the controls. PCR-DNA analysis was used to explore the genotype of the SNPs (rs4846048 and rs55763075) of the MTHFR 3'-UTR as well as the association between allelic frequencies and the CC risk. Then, the role of rs4846048 SNPs in the association of microRNA-522 (miR-522) and MTHFR was evaluated through luciferase reporter assay. Meanwhile, the modulatory influence of miR-522 on cell apoptosis and viability of Hela cells was also detected by flow cytometry and MTT assay.
resultsThe rs4846048 AG and G allele frequencies were significantly higher in CC subgroup compared with the control group. Methylenetetrahydrofolate reductase rs4846048 A/G alleles contributed to miR-522 binding, and miR-522 negatively modulated the expressions of MTHFR. Furthermore, miR-522 overexpression increased cell viability but decreased apoptotic cells in Hela cells.
conclusionThe preliminary report revealed that the SNP rs4846048 of MTHFR enhanced the risk of CC through association with miR-522, which further regulated cell viability and apoptosis in Hela cells.
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