ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2020
TCD Cerebral Hemodynamic Changes during Moderate-Intensity Exercise in Older Adults.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.Scientific reports · 2023Trial
- Cerebral Resistance Artery Histological Remodeling After Training-Sex Differences.Life (Basel, Switzerland) · 2025Article
- Effects of Physical Exercise on Cerebral Blood Velocity in Older Adults: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2023Review
- Hippocampal blood flow rapidly and preferentially increases after a bout of moderate-intensity exercise in older adults with poor cerebrovascular health.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.European journal of applied physiology · 2022Article
- Cerebrovascular response to exercise interacts with individual genotype and amyloid-beta deposition to influence response inhibition with aging.Neurobiology of aging · 2022Article
- Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease.Frontiers in physiology · 2022Article
- Cerebrovascular response to an acute bout of low-volume high-intensity interval exercise and recovery in young healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Chronic hyperglycemia before acute ischemic stroke impairs the bilateral cerebrovascular response to exercise during the subacute recovery period.Brain and behavior · 2021Article
- Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults.Nutrients · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeExercise plays an important role in supporting overall brain health. However, the mechanisms by which exercise supports brain health are imprecisely defined. Further, brain hemodynamic changes during exercise are not clearly understood, especially in older adults. The primary aim of this study was to compare cerebral blood flow velocity and pulsatility index (PI) during moderate-intensity exercise between older adults with normal pulsatile flow (normal PI) and older adults with elevated pulsatile flow (elevated PI). Secondary aims were to compare cardiovascular disease risk and cognitive function between individuals with elevated and nonelevated PI.
methodsUsing transcranial Doppler ultrasound (TCD), middle cerebral artery blood velocity (MCAv) and PI were recorded during the rest and moderate-intensity exercise. End tidal carbon dioxide (P
resultsWe enrolled 104 older adults into the study. The change in PI was greater in normal PI group (35.5% vs. 21.3%, P = .005). The change in MCAv was similar in both groups (11.6% for normal PI vs. 10.6% for elevated PI; P = .22). There was no significant difference in cardiovascular disease risk between the two groups (P = .77). Individuals with elevated PI performed significantly worse in WAIS-R Digit Symbol and Trail Making Test A (P = .04 and = .01, respectively).
conclusionsThe percent increase in PI from rest to moderate-intensity exercise was attenuated in the older adults with elevated resting PI. Higher resting PI may negatively affect brain health as evidenced by the slower processing speed scores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.