Evidence map›Paper›PMID 31750243›Full record

ArticleFrontiers in oncology2019

Fighting Cancer Stem Cell Fate by Targeting LIS1 a WD40 Repeat Protein.

Felix M Brehar, Mihnea P Dragomir, George E D Petrescu, Radu M Gorgan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Felix M BreharDepartment of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Mihnea P DragomirDepartment of Surgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
George E D PetrescuDepartment of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Radu M GorganDepartment of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Clinical Emergency Hospital Bucharest · ROCarol Davila University of Medicine and Pharmacy · ROThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is one of the most frequent and devastating diseases. Previous reports have shown that radio and chemo-resistant cancer stem cell (CSC) population is primarily responsible for cancer recurrences after radiotherapy and chemotherapy. Other studies demonstrated that Lissencephaly-1 (LIS1) protein, also known as platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1), a dynein-binding protein involved in neural stem cell division, plays a crucial role in maintaining CSC population in hematological malignancies. Moreover, one recent report demonstrated that

Indexed as

cancer stem cellchemoresistanceLis1radioresistanceWD40 protein

Identifiers

PMID31750243
PMCPMC6843031
OpenAlexW2981529237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.