ArticleWorld journal of transplantation2019
Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression.
Article in World journal of transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Clinicopathological Correlation of Kidney Allograft Biopsies According to the Banff 2022 Classification.Cureus · 2026Article
- Finerenone in kidney transplantation: an underinvestigated agent: review of available evidence, existing gaps, and future directions.Clinical transplantation and research · 2026Review
- Changes by Era in Risk Factors and Outcomes Among Deceased Donor Kidney Transplant Recipients With Delayed Graft Function.Clinical transplantation · 2026Article
- Early Elevations in Donor-derived Cell-free DNA are Associated With Increased Risk of Future Rejection and Graft Dysfunction After Kidney Transplant.Transplantation direct · 2026Article
- Outcomes of Persistent Microvascular Inflammation in Repeated Kidney Allograft Biopsies.Clinical transplantation · 2025Article
- The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure.JCI insight · 2025Article
- Postkidney Transplant Delayed Graft Function Outcomes Are Not Worsened by Deceased Donor Type.Clinical transplantation · 2025Article
- Delayed graft function has comparable associations with early outcomes in primary and repeat transplant among deceased-donor kidney transplant recipients.Journal of nephrology · 2025Article
- Tacrolimus intrapatient variability and rejection are associated with inferior allograft outcomes after kidney transplantation.Frontiers in nephrology · 2025Article
- Positive B cell flow cytometry crossmatch without detectable donor-specific antibodies: true or false reactivity?Frontiers in immunology · 2025Article
- Urinary Chemokines CXCL9 and CXCL10 Are Non-Invasive Biomarkers of Kidney Transplant Rejection.Annals of transplantation · 2024Article
- Donor-Derived Cell-Free DNA at 1 Month after Kidney Transplantation Relates to HLA Class II Eplet Mismatch Load.Biomedicines · 2023Article
- Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5-year graft failure and mortality post 1-year protocol biopsy in kidney transplant recipients.Immunity, inflammation and disease · 2023Article
- Three-year Outcomes After Conversion From Monthly to Every 2-month Belatacept Maintenance Therapy in Kidney Transplant Recipients: Results From a Randomized Controlled Trial.Transplantation direct · 2023Article
- Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients: Treatment Response Rates and Value of Early Surveillance Biopsies.Transplantation direct · 2022Article
- Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights.Biomedicines · 2022Review
- How Should Acute T-cell Mediated Rejection of Kidney Transplants Be Treated: Importance of Follow-up Biopsy.Transplantation direct · 2022Article
- Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies.Kidney international · 2022Article
- Antibody-mediated rejection of renal allografts: diagnostic pitfalls and challenges.Physiological research · 2021Review
- The causes and frequency of kidney allograft failure in a low-resource setting: observational data from Iraqi Kurdistan.BMC nephrology · 2021Observational
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.
aimTo report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.
methodsIn a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.
resultsWe identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy (IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy (TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR (40%), TG (17%), and IFTA (13%). Most grafts failed within two years of post-transplant (36%). Subsequently, approximately 10%-15% of grafts failed every two years: > 2-4 years (16%), > 4-6 years (13%), > 6-8 years (11%), > 8-10 years (9%) and > 10 years (16%). AR was the most common cause of graft failure in the first six years (48%), whereas TG was the most prevalent cause of graft failure after 6 years (32%) of transplant.
conclusionIn the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure.
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