ArticleNeurology. Clinical practice2019
Multiple sclerosis is associated with low bone mineral density and osteoporosis.
Article in Neurology. Clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of osteoporosis/osteopenia in patients with multiple sclerosis (MS): a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Clinician-led, single-blind, randomised controlled trial evaluating the efficacy of a high-intensity resistance and impact training intervention for improving health-related quality of life in people with multiple sclerosis: protocol for STRONG-MS.BMJ open sport & exercise medicine · 2026Article
- Bone Mineral Density Loss in Relapsing-remitting Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Matched Case-control Study.International journal of preventive medicine · 2026Article
- Multiple sclerosis is associated with increased shoulder dislocations and aseptic loosening following reverse shoulder arthroplasty: a propensity matched analysis.Archives of orthopaedic and trauma surgery · 2025Article
- Body Composition and Its Outcomes and Management in Multiple Sclerosis: Narrative Review.Nutrients · 2025Review
- Linking Pathogenesis to Fall Risk in Multiple Sclerosis.Archives of internal medicine research · 2025Article
- Assessing osteoporosis awareness and knowledge levels of Turkish multiple sclerosis patients: an observational study.Archives of osteoporosis · 2024Observational
- Association of white matter hyperintensities with BMD, incident fractures, and falls in the UK Biobank cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- The Immunomodulatory Potential of Short-Chain Fatty Acids in Multiple Sclerosis.International journal of molecular sciences · 2024Review
- Multiple sclerosis in the elderly: a retrospective cohort study.Journal of neurology · 2024Article
- Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Effects of Exercise, Rehabilitation, and Nutritional Approaches on Body Composition and Bone Density in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis.Journal of functional morphology and kinesiology · 2023Review
- Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case-Control Study.Nutrients · 2023Article
- Risk of fracture in neuromyelitis optica spectrum disorder and multiple sclerosis: a nationwide cohort study in South Korea.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Low bone mineral density is associated with gray matter volume decrease in UK Biobank.Frontiers in aging neuroscience · 2023Article
- Review
- Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022Review
- Physical and Mental Health Comorbidities Among Adults With Multiple Sclerosis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis.Frontiers in neurology · 2022Article
- Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis-Results from a randomized, controlled, single-blind trial.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare measures of bone mineral density (BMD) between people with and without MS.
methodsUsing population-based administrative data from Manitoba, Canada, we identified people with MS who received BMD screening and controls who received BMD screening matched 5:1 on age, sex, region of residence, and date of BMD screening. We determined the BMD T-scores for the femoral neck, total hip, and lumbar spine and frequency of osteoporosis (defined as T-score -2.5 or lower). We compared the groups with respect to the femoral neck T-score using multivariable linear regression, adjusting for age, sex, region, disability, continuity of care, recent previous fracture, falls history, medication use, and comorbidities. We compared the odds of osteoporosis between groups using multivariable logistic regression analysis.
resultsWe identified 783 MS cases who underwent BMD screening and 3,915 matched controls. The mean (SD) femoral BMD T-score was lower in MS cases (-1.48 [1.08]) than in matched controls (-1.12 [0.98],
conclusionsPeople with MS have lower BMD and a higher prevalence of osteoporosis compared with people of similar age and sex without MS. These findings indicate the importance of addressing bone health as part of comprehensive MS care.
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Registered trials
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