Evidence map›Paper›PMID 31750012›Full record

ArticleMRS communications2019

Towards the directed evolution of protein materials.

Anton Kan, Neel S Joshi

Abstract read
In one paragraph

Article in MRS communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The Natural History of Integrons.Microorganisms · 2021
    Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anton KanWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United States.
Neel S JoshiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United States.

Funding

Investigating the role of natural and engineered curli fibers in mediating interactions with the gut epitheliumR01DK110770 · NIDDK · NORTHEASTERN UNIVERSITY · PI JOSHI, NEEL SATISH · 2017 to 2021
$1.9M
NIDDK NIH HHS R01 DK110770
6 · The paper itself

Abstract

Protein-based materials have emerged as a powerful instrument for a new generation of biological materials, with many chemical and mechanical capabilities. Through the manipulation of DNA, researchers can design proteins at the molecular level, engineering a vast array of structural building blocks. However, our capability to rationally design and predict the properties of such materials is limited by the vastness of possible sequence space. Directed evolution has emerged as a powerful tool to improve biological systems through mutation and selection, presenting another avenue to produce novel protein materials. In this prospective review, we discuss the application of directed evolution for protein materials, reviewing current examples and developments that could facilitate the evolution of protein for material applications.

Indexed as

Biological synthesisBiomaterialsDirected evolutionSynthetic biology

Identifiers

PMID31750012
PMCPMC6867688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.