ArticleBMJ open diabetes research & care2019
Nationwide trends in the epidemiology of diabetic foot complications and lower-extremity amputation over an 8-year period.
Article in BMJ open diabetes research & care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Effects of educational technologies on the prevention and treatment of diabetic ulcers: A systematic review and meta-analysis.Revista latino-americana de enfermagem · 2023Pooled it
- Economic evaluations considering costs and outcomes of diabetic foot ulcer infections: A systematic review.PloS one · 2020Pooled it
- Cost-effectiveness of Novel Macrophage-Regulating Treatment for Wound Healing in Patients With Diabetic Foot Ulcers From the Taiwan Health Care Sector Perspective.JAMA network open · 2023Trial
- Prognostic implications of single antiplatelet therapy in individuals developing diabetic foot disease with concurrent peripheral arterial disease.Annals of medicine · 2026Article
- Biochemical markers of bone metabolism and bone mineral density in patients with type 2 diabetic foot ulcer.BMC endocrine disorders · 2026Article
- War, amputation, and resilience: assessing health-related quality of life in Syrian prosthetic users.International journal for equity in health · 2025Article
- Omentin-1 promotes wound healing in diabetic mice by improving vascular endothelial cell function.Scientific reports · 2025Article
- Extracellular matrix repair and organization of chronic infected diabetic wounds treated with methacrylated chitosan-based hydrogels.Acta biomaterialia · 2025Article
- Health-related quality of life among lower limb amputees using prostheses in Nepal: a cross-sectional study.BMC sports science, medicine & rehabilitation · 2024Article
- Clinical outcomes in people with diabetes-related foot infections: Analysis from a limb preservation service infection database.Journal of foot and ankle research · 2024Article
- Two-year incidence and risk factors of diabetic foot ulcer: second phase report of Ahvaz diabetic foot cohort (ADFC) study.BMC endocrine disorders · 2024Article
- Characteristics and outcomes of diabetic foot ulcers treated with surgical debridement and standardized wound care.International wound journal · 2024Article
- Microbiome of limb-threatening diabetic foot ulcers indicates the association of fastidious Stenotrophomonas and major amputation.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2024Article
- 2024 TSOC/TSPS Joint Consensus: Strategies for Advanced Vascular Wound Management in Arterial and Venous Diseases.Acta Cardiologica Sinica · 2024Article
- Article
- Toward non-invasive collection methods for sampling the microbiome of diabetic foot ulcers.International wound journal · 2023Article
- A Designed Host Defense Peptide for the Topical Treatment of MRSA-Infected Diabetic Wounds.International journal of molecular sciences · 2023Article
- Preparation of therapy-grade extracellular vesicles from adipose tissue to promote diabetic wound healing.Frontiers in bioengineering and biotechnology · 2023Article
- Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Association of time in range with postoperative wound healing in patients with diabetic foot ulcers.International wound journal · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To study the prevalence and trends of lower extremity complications of diabetes over an 8-year period in a single nation. Research design and methods: Nationwide data for people with type 2 diabetes (T2D) and diabetic foot complications (DFCs) were analyzed over an 8-year period (2007-2014) from National Health Insurance Research Database using the International Classification of Diseases, Ninth Revision disease coding. The DFCs were defined as ulcers, infections, gangrene, and hospitalization for peripheral arterial disease (PAD). Trends of patient characteristics, foot presentation, and the execution of major procedures were studied, including lower-extremity amputations (LEAs). Results: Along with the T2D population increasing over time, the absolute number of people with DFCs increased by 33.4%, but retained a prevalence of around 2% per year. The annual incident of LEAs decreased from 2.85 to 2.06 per 1000 T2D population (p=0.001) with the major LEA proportion decreasing from 56.2% to 47.4% (p<0.001).The mean age of patients increased from 65.3 to 66.3 years and most of the associated comorbidities of diabetes were increased. For example, end-stage renal disease increased from 4.9% to 7.7% (p=0.008). The incidence of gangrene on presentation decreased from 14.7% to 11.3% (p<0.001) with a concomitant increase in vascular interventions (6.2% to 19.5%, p<0.001). Conclusions: DFCs remain a sustained major medical problem. These nationwide long-term data suggest trends toward older people with greater comorbidities such as PAD and renal disease. Nevertheless, promising trends of reducing gangrene on presentation paired with increases in vascular interventions support continued vigilance and rapid, coordinated interdisciplinary diabetic foot care.
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