Evidence map›Paper›PMID 31749842›Full record

ArticleFrontiers in genetics2019

Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter.

Ashley L Green, Aseel Eid, Le Zhan, Helmut Zarbl, Grace L Guo, Jason R Richardson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Attention-deficit/hyperactive disorder updates.Frontiers in molecular neuroscience · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ashley L GreenEnvironmental and Occupational Health Sciences Institute and Department of Environmental and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, United States.
Aseel EidDepartment of Environmental Health Sciences, Robert Stempel School of Public Health and Social Work, Florida International University, Miami, FL, United States.
Le ZhanDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States.
Helmut ZarblEnvironmental and Occupational Health Sciences Institute and Department of Environmental and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, United States.
Grace L GuoEnvironmental and Occupational Health Sciences Institute and Department of Environmental and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, United States.
Jason R RichardsonEnvironmental and Occupational Health Sciences Institute and Department of Environmental and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, United States.
Rutgers, The State University of New Jersey · USEnvironmental and Occupational Health Sciences Institute · USFlorida International University · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHDR01ES015991 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI RICHARDSON, JASON R · 2007 to 2011
$3.2M
Gene-Environment Interactions in Neurodegeneration: Role of Efflux TransportersR01ES021800 · NIEHS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI ALEKSUNES, LAUREN M, RICHARDSON, JASON R · 2014 to 2018
$1.9M
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasisR01GM104037 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2013 to 2016
$1.1M
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES015991NIEHS NIH HHS R01 ES021800NIEHS NIH HHS T32 ES007148NIGMS NIH HHS R01 GM104037
6 · The paper itself

Abstract

The dopamine transporter (DAT) is a plasma membrane transport protein responsible for regulating the duration and intensity of dopaminergic signaling. Altered expression of DAT is linked to neurodevelopmental disorders, including attention deficit hyperactivity disorder and autism spectrum disorder, and is shown to contribute to the response of psychotropic drugs and neurotoxicants. Although the postnatal levels of DAT have been characterized, there are few data regarding the mechanisms that regulate postnatal DAT expression. Here, we examine the ontogeny of DAT mRNA from postnatal days 0 to 182 in the rat brain and define a role for epigenetic mechanisms regulating DAT expression. DAT mRNA and protein significantly increased between PND 0 and 6 months in rat midbrain and striatum, respectively. The epigenetic modifiers

Indexed as

dopamine transporterepigeneticshistone modificationsNurr1ontogenyPitx3

Identifiers

PMID31749842
PMCPMC6844290
OpenAlexW2984616139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.