ArticleFrontiers in genetics2019
The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Telomere Dynamics in Livestock.Biology · 2023Review
- Article
- Comparison of Telomere Length in Age-Matched Primiparous and Multiparous Brahman Cows.Animals : an open access journal from MDPI · 2023Article
- Prenatal environment impacts telomere length in newborn dairy heifers.Scientific reports · 2023Article
- Molecular Cytogenetics in Domestic Bovids: A Review.Animals : an open access journal from MDPI · 2023Review
- Characterization of telomere length in Agerolese cattle breed, correlating blood and milk samples.Animal genetics · 2022Article
- Causes and consequences of variation in early-life telomere length in a bird metapopulation.Ecology and evolution · 2022Article
- The tarnished silver spoon? Trade-off between prenatal growth and telomere length in wild boar.Journal of evolutionary biology · 2022Article
- Longer telomeres during early life predict higher lifetime reproductive success in females but not males.Proceedings. Biological sciences · 2021Article
- Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle.Scientific reports · 2021Article
- Genomic Analysis, Progress and Future Perspectives in Dairy Cattle Selection: A Review.Animals : an open access journal from MDPI · 2021Review
- Genomic Evaluation of Primiparous High-Producing Dairy Cows: Inbreeding Effects on Genotypic and Phenotypic Production-Reproductive Traits.Animals : an open access journal from MDPI · 2020Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health and survival are key goals for selective breeding in farm animals. Progress, however, is often limited by the low heritability of these animal fitness traits in addition to measurement difficulties. In this respect, relevant early-life biomarkers may be useful for breeding purposes. Telomere length (TL), measured in leukocytes, is a good candidate biomarker since TL has been associated with health, ageing, and stress in humans and other species. However, telomere studies are very limited in farm animals. Here, we examined the genetic background, genomic architecture, and factors affecting bovine TL measurements in early life, and the association of the latter with animal fitness traits expressed later in life associated with survival, longevity, health, and reproduction. We studied two TL measurements, one at birth (TLB) and another during the first lactation (TLFL) of a cow. We performed a genome-wide association study of dairy cattle TL, the first in a non-human species, and found that TLB and TLFL are complex, polygenic, moderately heritable, and highly correlated traits. However, genomic associations with distinct chromosomal regions were identified for the two traits suggesting that their genomic architecture is not identical. This is reflected in changes in TL throughout an individual's life. TLB had a significant association with survival, length of productive life and future health status of the animal, and could be potentially used as an early-life biomarker for disease predisposition and longevity in dairy cattle.
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