Evidence map›Paper›PMID 31749650›Full record

SynthesisDialogues in clinical neuroscience2019

Nonpharmacological treatment of dyscognition in schizophrenia: effects 
of aerobic exercise
.

Isabel Maurus, Astrid Röh, Peter Falkai, Berend Malchow, Andrea Schmitt, Alkomiet Hasan

Open access · diamondAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in Dialogues in clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Neurocognitive deficits in schizophrenia are likely to be less severe and less related to the disorder than previously thought.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Isabel MaurusDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany.
Astrid RöhDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany.
Berend MalchowDepartment of Psychiatry and Psychotherapy, Unversity Hopsital of Jena, Jena, Germany.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of São Paulo, São Paulo, Brazil.
Alkomiet HasanDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive symptoms are a core feature of schizophrenia and are related to an unfavorable disease outcome. So far, there are no satisfactory pharmacological approaches to address cognitive symptoms. For some time now, aerobic exercise has been demonstrated in various trials to be a promising candidate for this indication. The aim of this brief qualitative review was to present the most recent meta-analyses regarding the capacity of exercise to improve cognition in schizophrenia patients. Additionally, we give a short overview of the effects in other conditions, like healthy subjects and patients with major depression. We conducted a focused literature search using the PubMed database, concentrating on meta-analyses which are based on a systematic search. The most recent meta-analysis investigating the efficacy of aerobic exercise on cognitive impairments in schizophrenia patients provides evidence that exercise has positive effects on cognitive functioning in this population. However, the effect seems not to be specific; there were positive findings regarding healthy subjects and patients with depressive disorders as well, even if they were less consistent. As most available trials have a small to modest sample size and have no consensus with regard to the intervention regime, nor to the assessment of cognition, the findings are difficult to generalize. In the future, standardized clinical trials focusing on the long-term effects of exercise are needed to evaluate whether the improvements in cognition are sustainable.
.

Indexed as

Schizophrenic PsychologyClinical Trials as TopicCognitive DysfunctionExerciseHumansSchizophreniaTreatment Outcomeaerobic exercisecognitionhealthy subjectmajor depressionmeta-analysisschizophrenia

Identifiers

PMID31749650
PMCPMC6829165
OpenAlexW2990836270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.