Evidence map›Paper›PMID 31749648›Full record

ReviewDialogues in clinical neuroscience2019

Cognitive impairment in psychotic illness: prevalence, profile of impairment, developmental course, and treatment considerations
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Amanda McCleery, Keith H Nuechterlein

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dialogues in clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06482918 (Cognitive Remediation in Schizophrenia Patients), which is not on this map. Cited by 131 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 5 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06482918 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Cognitive Remediation in Schizophrenia Patients: Study of the Efficacy and of the Role of Neuroplasticity in Two Different Approaches Based on "Top-down" and "Bottom-up" Mechanisms

TypeinterventionalSponsorUniversity of ChileRan2024 to 2026Enrolled160ConditionsSchizophreniaArmsCognitive Remediation
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 5 syntheses or guidelines pooled it, 229 citations in OpenAlex.

  1. Pooled it
  2. Efficacy and safety of tACS in older adults with cognitive impairment: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Article
  12. Understanding the burden of cognitive impairment associated with schizophrenia: Results from the international LUCIA study.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Are cognitive deficits more severe among people with treatment-resistant schizophrenia than treatment responders?Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2026
    Article
  17. Cognitive and clinical profiles in first-episode psychosis and their relationship with functional outcomes.The British journal of psychiatry : the journal of mental science · 2026
    Article
  18. Article
  19. Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amanda McCleeryUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, US; VA Greater Los Angeles, VISN 22 MIRECC, Los Angeles, California, US.
Keith H NuechterleinUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, US; UCLA Department of Psychology, Los Angeles, California, US.
Mental Illness Research, Education and Clinical Centers · US

Funding

Enhancing Cognitive Training Through Exercise Following a First Schizophrenia EpisodeR01MH110544 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2016 to 2022
$7.3M
Cognitive and Affective Dysfunctions in the PsychosesT32MH096682 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2013 to 2018
$1.1M
Cortical Plasticity Across Phase of Illness in SchizophreniaK23MH108829 · NIMH · UNIVERSITY OF IOWA · PI MCCLEERY, AMANDA · 2016 to 2022
$910k
NIMH NIH HHS K23 MH108829NIMH NIH HHS R01 MH110544NIMH NIH HHS T32 MH096682
6 · The paper itself

Abstract

Despite effective pharmacological treatments for psychotic symptoms (eg, hallucinations, delusions), functional outcomes for people with psychotic disorders are often disappointing. Although it is not included in the diagnostic criteria for psychotic disorders, cognitive impairment is one of the strongest determinants of community functioning in this clinical population, and thus it is an important target for intervention. In this review, we discuss the major areas of research regarding impaired cognition in psychotic illness. The specific topics covered include: (i) the prevalence of cognitive impairment in psychotic disorders; (ii) the profile and magnitude of cognitive impairment in psychotic disorders; (iii) the developmental course of cognitive impairment; (iv) the longitudinal stability of cognitive impairment; and (v) treatment approaches to improve cognitive performance in people with psychotic disorders.
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Indexed as

Antipsychotic AgentsCognitive Behavioral TherapyCognitive DysfunctionHumansNootropic AgentsPrevalencePsychotic DisordersTreatment OutcomeAntipsychotic AgentsNootropic Agentsaffective psychosisclinical high riskcognitioncognitive enhancementcognitive impairmentcognitive trainingexerciseneurodevelopmental modelpharmaceutical agentpsychosisschizophreniatDCS

Identifiers

PMID31749648
PMCPMC6829172
OpenAlexW3019591675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.