Evidence map›Paper›PMID 31749341›Full record

ReviewThe world journal of men's health2021

A Novel Approach to Improving the Reliability of Manual Semen Analysis: A Paradigm Shift in the Workup of Infertile Men.

Christopher Douglas, Neel Parekh, Linda G Kahn, Ralf Henkel, Ashok Agarwal

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The world journal of men's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Male Fertility as a Proxy for Health.Journal of clinical medicine · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Microenvironment for spermatogenesis and sperm maturation.Histochemistry and cell biology · 2022
    Review
  15. Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction.Advances in experimental medicine and biology · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Christopher DouglasAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0001-5010-5618
Neel ParekhAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0002-6218-9254
Linda G KahnAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0002-6512-6160
Ralf HenkelAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0003-1128-2982
Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA. agarwaa@ccf.org.ORCID https://orcid.org/0000-0003-0585-1026
American Society for Reproductive Medicine · USCleveland Clinic · US

Funding

Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthR00ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2022 to 2024
$746k
Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthK99ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2019 to 2020
$220k
American Center for Reproductive MedicineNIEHS NIH HHS K99 ES030403NIEHS NIH HHS K99ES030403NIEHS NIH HHS R00 ES030403
6 · The paper itself

Abstract

Conventional semen analysis (SA) is an essential component of the male infertility workup, but requires laboratories to rigorously train and monitor technicians as well as regularly perform quality assurance assessments. Without such measures there is room for error and, consequently, unreliable results. Furthermore, clinicians often rely heavily on SA results when making diagnostic and treatment decisions, however conventional SA is only a surrogate marker of male fecundity and does not guarantee fertility. Considering these challenges, the last several decades have seen the development of many advances in SA methodology, including tests for sperm DNA fragmentation, acrosome reaction, and capacitation. While these new diagnostic tests have improved the scope of information available to clinicians, they are expensive, time-consuming, and require specialized training. The latest advance in laboratory diagnostics is the measurement of seminal oxidation-reduction potential (ORP). The measurement of ORP in an easy, reproducible manner using a new tool called the Male Infertility Oxidative Stress System (MiOXSYS) has demonstrated ORP's potential as a feasible adjunct test to conventional SA. Additionally, the measurement of ORP by this device has been shown to be predictive of both poor semen quality and male infertility. Assessing ORP is a novel approach to both validating manual SA results and identifying patients who may benefit from treatment of male oxidative stress infertility.

Indexed as

Infertility, MaleMiOXSYSOxidation-reduction potentialSemen analysisSemen analysis subjectivity

Identifiers

PMID31749341
PMCPMC7994658
OpenAlexW2989960370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.