ArticleBrain and behavior2019
Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Obstructive sleep apnea and attention deficits: A systematic review of magnetic resonance imaging biomarkers and neuropsychological assessments.Brain and behavior · 2023Pooled it
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- White matter microstructure differences in obstructive sleep apnea severity groups assessed by diffusion tensor metrics and biophysical modeling.Scientific reports · 2026Article
- Programmed cell death in the cognitive impairment of obstructive sleep apnea.Cell & bioscience · 2025Review
- Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Biophysical modeling and diffusion kurtosis imaging reveal microstructural alterations in normal-appearing white-matter regions of the brain in obstructive sleep apnea.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study.Nature and science of sleep · 2024Article
- More extensive white matter disruptions present in untreated obstructive sleep apnea than we thought: A large sample diffusion imaging study.Human brain mapping · 2023Article
- Machine learning approach for obstructive sleep apnea screening using brain diffusion tensor imaging.Journal of sleep research · 2023Article
- Evaluation of the corpus callosum shape in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Article
- Effects of 3-month CPAP therapy on brain structure in obstructive sleep apnea: A diffusion tensor imaging study.Frontiers in neurology · 2022Article
- Obstructive Sleep Apnea and the Brain: a Focus on Gray and White Matter Structure.Current neurology and neuroscience reports · 2021Review
- The Impacts of Obstructive Sleep Apnea Severity on Brain White Matter Integrity and Cognitive Functions in Children: A Diffusion Tensor Imaging Study.Nature and science of sleep · 2021Article
- Digital sleep measures and white matter health in the Framingham Heart Study.Exploration of medicine · 2021Article
- Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease.Frontiers in aging neuroscience · 2021Article
- Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.Human brain mapping · 2020Article
- Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea.Brain and behavior · 2019Article
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Authors and funding
8 authors.
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Abstract
backgroundThere is some evidence that obstructive sleep apnea (OSA) patients have white matter integrity abnormality in the corpus callosum (CC). However, whether the CC subregions are differentially affected in OSA is largely unknown.
methodsTwenty patients with OSA and 24 well-matched healthy controls were enrolled and underwent diffusion tensor imaging (DTI) and clinical and cognitive assessments. DTI tractography was used to reconstruct the CC which was divided into five subregions. Intergroup differences in multiple diffusion metrics of each CC subregion and their correlations with clinical and cognitive parameters were tested.
resultsIn comparison with healthy controls, OSA patients exhibited white matter integrity alterations in the anterior CC, characterized by increased radial diffusivity (RD) in the subregion 1 and decreased fractional anisotropy (FA) along with increased mean diffusivity (MD) and RD in the subregion 2. Moreover, we found that the lower microstructural integrity in the anterior CC was correlated with worse prospective memory and sustained attention in OSA patients.
conclusionsThese findings indicate that the selective impairments of the anterior CC may help clarify the neural correlates of cognitive impairments in OSA.
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