ReviewDermatology and therapy2020
Pathogenesis, Clinical Signs and Treatment Recommendations in Brittle Nails: A Review.
Review in Dermatology and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Corrective and Restorative Dermatology in Cancer Survivors: An Urgent Unmet Need!American journal of clinical dermatology · 2026Review
- Ultrasound Evaluation of Cosmetic Changes in Nails: A Case Series and Literature Review.Cureus · 2025Article
- Nail Supplements: When, How, and Why?Skin appendage disorders · 2025Review
- Dermoscopic Evaluation of Nail Changes in Patients with End-Stage Renal Disease on Regular Hemodialysis.Skin appendage disorders · 2025Article
- Changes of plasma amino acid levels and metabolic pathways in isotretinoin therapy: ınsights into managing acne vulgaris side effects.Archives of dermatological research · 2025Article
- Effectiveness and Safety of Intramatricial Triamcinolone Acetonide for Trachyonychia: A Retrospective Data Analysis.Skin appendage disorders · 2025Article
- Treatment of Onychomycosis and the Drug-Drug Interactions in Patients with Diabetes Mellitus and Diabetic Foot Syndrome: A Systematic Review.Infectious disease reports · 2025Review
- Nails in older adults.Annals of medicine · 2024Review
- Alopecia Areata of the Nails: Diagnosis and Management.Journal of clinical medicine · 2024Review
- Exposome Impact on Nail Health.Skin appendage disorders · 2024Review
- Natural Treatment Options for Nail Disorders.Skin appendage disorders · 2024Review
- Toenail and serum levels as biomarkers of iron status in pre- and postmenopausal women: correlations and stability over eight-year follow-up.Scientific reports · 2024Article
- Unveiling Skin Manifestations: Exploring Cutaneous Signs of Malnutrition in Eating Disorders.Cureus · 2023Review
- Recognizing skin conditions in patients with cirrhosis: a narrative review.Annals of medicine · 2022Review
- Optimal diagnosis and management of common nail disorders.Annals of medicine · 2022Review
- Leukonychia: What Can White Nails Tell Us?American journal of clinical dermatology · 2022Review
- Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer.Pharmaceutics · 2020Article
- Efficacy and Acceptability of a New Water-Soluble Nail Strengthener ContainingSkin appendage disorders · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nail plate brittleness (or fragility) is a common complaint affecting up to 20% of the population, especially women over 50 years of age, with fingernail fragility being more prevalent than toenail fragility. Nail brittleness is characterized by nails that split, flake and crumble, become soft and lose elasticity. The main clinical presentations are: onychoschizia, onychorrhexis, superficial granulation of keratin and worn-down nails. According to causative factors, we can distinguish 2 forms of nail fragility (NF): a primary "idiopathic or brittle nail syndrome" form and NF secondary to different causes such as inflammatory nail disorders, infections, systemic diseases and general conditions, traumas and alteration of the nail hydration. Optimal management requires treatment of the primary cause of brittle nails, when possible. In idiopathic NF oral supplementation, vitamins (especially biotin, also known as vitamin B7), trace elements and amino acids (especially cysteine) have been reported to be useful. In addition, several products, such as topical moisturizers and lacquers could be considered to restructure the affected nail plate and to reduce psychological impacts of this common problem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.