Evidence map›Paper›PMID 31749034›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2020

ISCEV extended protocol for the S-cone ERG.

Ido Perlman, Mineo Kondo, Enid Chelva, Anthony G Robson, Graham E Holder

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07748715 (Blue Color Processing in the Eye as a Biomarker of Brain Dopamine), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07748715 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Blue Color Processing in the Eye as a Biomarker of Brain Dopamine

TypeobservationalSponsorUniversity of South FloridaRan2026 to 2027Enrolled50ConditionsParkinson Disease, Healthy Adult ParticipantsArmsLevadopa/Carbidopa eyedrops, Sham, Levodopa/Carbidopa (Sinemet)
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. ISCEV and IPS guideline for the full-field stimulus test (FST).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Guideline
  2. Enhanced S-cone syndrome in a family: first long-term (12-year) follow-up and literature review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Inner retinal cavitations in three cases of NR2E3-associated retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  5. Measuring electroretinograms in tree shrews with a portable electrophysiology device.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  6. Article
  7. Review
  8. S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026
    Article
  9. Article
  10. ISCEV standard for clinical visual evoked potentials (2025 update).Documenta ophthalmologica. Advances in ophthalmology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. ISCEV standard for clinical pattern electroretinography (2024 update).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. IMI-Management and Investigation of High Myopia in Infants and Young Children.Investigative ophthalmology & visual science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ido PerlmanRuth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. iperlman@technion.ac.il.ORCID 0000-0001-9505-6979
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Enid ChelvaDepartment of Medical Technology and Physics, Sir Charles Gairdner Hospital, Nedlands, Australia.
Anthony G RobsonMoorfield Eye Hospital and Institute of Ophthalmology, University College London, London, UK.
Graham E HolderNational University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure for testing generalized retinal function but encourages more extensive testing. This extended protocol describes a method of assessing the function of the short-wavelength-sensitive cone (S-cone) retinal pathway, using a short-wavelength flash superimposed on a background that saturates the rods and adapts the L/M-cones to elicit a response, known as the S-cone ERG. Stimulus parameters such as the strength and luminance of the flash and background, respectively, and their spectral and temporal characteristics are specified. As a complement to the ISCEV standard, testing the S-cone ERG enables further characterization of light-adapted retinal function and may refine diagnosis of some retinal disorders. Typical applications are described including use in the diagnosis of rod monochromacy and S-cone monochromacy, identification and investigation of cone On-bipolar cell dysfunction and use of the technique to confirm the diagnosis of enhanced S-cone syndrome.

Indexed as

Adaptation, OcularCalibrationClinical ProtocolsElectrophysiologyElectroretinographyHumansInternational AgenciesPhotic StimulationRetinal Cone Photoreceptor CellsRetinal DystrophiesRod OpsinsSocieties, MedicalVision, OcularRod Opsinsshort-wavelength opsinClinical standardsElectroretinogram (ERG)Full-field ERGInternational Society for Clinical Electrophysiology of Vision (ISCEV)Retinal dystrophyRetinopathyS-cone ERGShort-wavelength-sensitive cone ERG

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.