ArticleEuropean radiology2020
ZTE MR-based attenuation correction in brain FDG-PET/MR: performance in patients with cognitive impairment.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Comparison of pointwise encoding time reduction with radial acquisition (PETRA) imaging with conventional MR imaging for the diagnosis of traumatic fractures in children.BMC medical imaging · 2025Article
- Quantification of FDG in the spinal cord using PET/MRI.Frontiers in nuclear medicine · 2025Article
- Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging.Diagnostics (Basel, Switzerland) · 2024Review
- A review of PET attenuation correction methods for PET-MR.EJNMMI physics · 2023Review
- Unsupervised-learning-based method for chest MRI-CT transformation using structure constrained unsupervised generative attention networks.Scientific reports · 2022Article
- Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [EJNMMI physics · 2020Article
- Attenuation correction for human PET/MRI studies.Physics in medicine and biology · 2020Article
- Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation.An international journal on information fusion · 2020Article
- Validation of PET/MRI attenuation correction methodology in the study of brain tumours.BMC medical imaging · 2020Article
- Zero Echo Time MRAC on FDG-PET/MR Maintains Diagnostic Accuracy for Alzheimer's Disease; A Simulation Study Combining ADNI-Data.Frontiers in neuroscience · 2020Article
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Abstract
objectiveOne of the main challenges of integrated PET/MR is to achieve an accurate PET attenuation correction (AC), especially in brain acquisition. Here, we evaluated an AC method based on zero echo time (ZTE) MRI, comparing it with the single-atlas AC method and CT-based AC, set as reference.
methodsFifty patients (70 ± 11 years old, 28 men) underwent FDG-PET/MR examination (SIGNA PET/MR 3.0 T, GE Healthcare) as part of the investigation of suspected dementia. They all had brain computed tomography (CT), 2-point LAVA-flex MRI (for atlas-based AC), and ZTE-MRI. Two AC methods were compared with CT-based AC (CTAC): one based on a single atlas, one based on ZTE segmentation. Impact on brain metabolism was evaluated using voxel and volumes of interest-based analyses. The impact of AC was also evaluated through comparisons between two subgroups of patients extracted from the whole population: 15 patients with mild cognitive impairment and normal metabolic pattern, and 22 others with metabolic pattern suggestive of Alzheimer disease, using SPM12 software.
resultsZTE-AC yielded a lower bias (3.6 ± 3.2%) than the atlas method (4.5 ± 6.1%) and lowest interindividual (4.6% versus 6.8%) and inter-regional (1.4% versus 2.6%) variabilities. Atlas-AC resulted in metabolism overestimation in cortical regions near the vertex and cerebellum underestimation. ZTE-AC yielded a moderate metabolic underestimation mainly in the occipital cortex and cerebellum. Voxel-wise comparison between the two subgroups of patients showed that significant difference clusters had a slightly smaller size but similar locations with PET images corrected with ZTE-AC compared with those corrected with CT
conclusionZTE-AC performed better than atlas-AC in detecting pathologic areas in suspected neurodegenerative dementia. KEY POINTS: • The ZTE-based AC improved the accuracy of the metabolism quantification in PET compared with the atlas-AC method. • The overall uptake bias was 21% lower when using ZTE-based AC compared with the atlas-AC method. • ZTE-AC performed better than atlas-AC in detecting pathologic areas in suspected neurodegenerative dementia.
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