ArticleEuropean radiology experimental2019
Associations of thigh muscle fat infiltration with isometric strength measurements based on chemical shift encoding-based water-fat magnetic resonance imaging.
Article in European radiology experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Clinical Sensitivity of Sub-millimetre-resolution Definite Versus Thin Inter-/Intramuscular Fat Streaks from Calf and Thigh MRI.Calcified tissue international · 2026Article
- Integrating intramuscular fat radiomics with hamstrings-to-quadriceps structure and function ratios to predict future hamstring strain injury.PLOS digital health · 2025Article
- Musculoskeletal manifestations of COVID-19.Skeletal radiology · 2024Review
- Deep network and multi-atlas segmentation fusion for delineation of thigh muscle groups in three-dimensional water-fat separated MRI.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Association of mid-thigh quadriceps muscle quality with postoperative outcomes in patients with hip osteoarthritis undergoing total hip arthroplasty: a retrospective cohort study.International orthopaedics · 2024Article
- From surgery to functional capacity: muscle strength modifications in women post sleeve gastrectomy.BMC sports science, medicine & rehabilitation · 2024Article
- Clinical and biomechanical outcomes following patellar tendon repair with suture tape augmentation.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Sitting vs. supine ultrasound measurements of the vastus medialis: correlations with MRI measurements and age considerations.Journal of physiological anthropology · 2023Article
- Deep learning-based automatic pipeline for quantitative assessment of thigh muscle morphology and fatty infiltration.Magnetic resonance in medicine · 2023Article
- Midterm outcome and strength assessment after quadriceps tendon refixation with suture anchors.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Factors of Muscle Quality and Determinants of Muscle Strength: A Systematic Literature Review.Healthcare (Basel, Switzerland) · 2022Review
- Sex-Specific Changes in Physical Risk Factors for Anterior Cruciate Ligament Injury by Chronological Age and Stages of Growth and Maturation From 8 to 18 Years of Age.Journal of athletic training · 2022Article
- The effect of ageing on fat infiltration of thigh and paraspinal muscles in men.Aging clinical and experimental research · 2022Article
- Do Preoperative Vastus Medialis Volume and Quality Affect Functional Outcomes after Total Knee Arthroplasty?Journal of clinical medicine · 2022Article
- Muscle weakness is associated with non-contractile muscle tissue of the vastus medialis muscle in knee osteoarthritis.BMC musculoskeletal disorders · 2022Article
- A Review on Aging, Sarcopenia, Falls, and Resistance Training in Community-Dwelling Older Adults.International journal of environmental research and public health · 2022Review
- Proton density fat fraction: magnetic resonance imaging applications beyond the liver.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Review
- Intramuscular fat in gluteus maximus for different levels of physical activity.Scientific reports · 2021Article
- Improvement in Muscle Strength and Metabolic Parameters Despite Muscle Mass Loss in the Initial Six Months After Bariatric Surgery.Obesity surgery · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment of the thigh muscle fat composition using magnetic resonance imaging (MRI) can provide surrogate markers in subjects suffering from various musculoskeletal disorders including knee osteoarthritis or neuromuscular diseases. However, little is known about the relationship with muscle strength. Therefore, we investigated the associations of thigh muscle fat with isometric strength measurements.
methodsTwenty healthy subjects (10 females; median age 27 years, range 22-41 years) underwent chemical shift encoding-based water-fat MRI, followed by bilateral extraction of the proton density fat fraction (PDFF) and calculation of relative cross-sectional area (relCSA) of quadriceps and ischiocrural muscles. Relative maximum voluntary isometric contraction (relMVIC) in knee extension and flexion was measured with a rotational dynamometer. Correlations between PDFF, relCSA, and relMVIC were evaluated, and multivariate regression was applied to identify significant predictors of muscle strength.
resultsSignificant correlations between the PDFF and relMVIC were observed for quadriceps and ischiocrural muscles bilaterally (p = 0.001 to 0.049). PDFF, but not relCSA, was a statistically significant (p = 0.001 to 0.049) predictor of relMVIC in multivariate regression models, except for left-sided relMVIC in extension. In this case, PDFF (p = 0.005) and relCSA (p = 0.015) of quadriceps muscles significantly contributed to the statistical model with R
conclusionChemical shift encoding-based water-fat MRI could detect changes in muscle composition by quantifying muscular fat that correlates well with both extensor and flexor relMVIC of the thigh. Our results help to initiate early, individualised treatments to maintain or improve muscle function in subjects who do not or not yet show pathological fatty muscle infiltration.
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