ArticleNature2019
PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
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Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
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Who cites it
92 citing papers in PubMed, 151 citations in OpenAlex.
- Article
- A proteogenomic RNA processing mechanism drives sex differences in meningioma.Research square · 2026Article
- Regulatory heme: a mitochondria-to-nucleus messenger of CD8Cellular & molecular immunology · 2026Article
- Regulatory interplay between nitric oxide and heme in redox signaling and inflammation.Redox biology · 2026Review
- Article
- Sorghum bicolor membrane steroid binding protein 1 can bind heme and remodel ER membranes.Plant & cell physiology · 2026Article
- Overexpression of PGRMC2 in astrocytes improved cognitive function in a mouse model of Alzheimer's disease by modulating neuroinflammation.Journal of translational medicine · 2026Article
- Heme limitation induces LHR2, an essential gene for Leishmania pathogenesis.PLoS pathogens · 2026Article
- Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions.Journal of inorganic biochemistry · 2026Article
- Key roles of GAPDH, Hsp90, and NO in heme trafficking.Journal of inorganic biochemistry · 2026Review
- Macrophage Polarization-Related Biomarkers in Epilepsy: Integrated Bioinformatics Analysis and Clinical Validation.Journal of inflammation research · 2026Article
- Progesterone signaling in cardio-renal physiology and pathophysiology.Frontiers in endocrinology · 2026Review
- Identification of PGRMC1 as a regulator of the TLR3-TICAM1-IFNβ1 signaling axis in RAW264.7 macrophages.Biochemistry and biophysics reports · 2025Article
- Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets.Nature communications · 2025Article
- FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis.Experimental hematology · 2025Article
- Targeting MondoA-TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment.Nature metabolism · 2025Article
- Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.Nature communications · 2025Article
- From Deficiency to Therapy: Systemic Consequences of ALAS1 Disruption and the Protective Role of 5-ALA.Life (Basel, Switzerland) · 2025Review
- Mechanisms of heme transport in the mitochondria.Biochemical Society transactions · 2025Review
- Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Andrea GalmozziDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Bernard P KokDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Arthur S KimDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
J Rafael Montenegro-BurkeScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Jae Y LeeDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Roberto SpreaficoInstitute for Quantitative and Computational Biology, University of California, Los Angeles, CA, USA.
Sarah MosureDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Verena AlbertDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Rigo Cintron-ColonDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Cristina GodioDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
William R WebbScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Bruno ContiDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Laura A SoltDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Douglas KojetinDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL, USA.
Christopher G ParkerDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
John J PelusoDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA.
James K PruCenter for Reproductive Biology, Department of Animal Sciences, Washington State University, Pullman, WA, USA.
Gary SiuzdakScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Benjamin F CravattDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Enrique SaezDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA. esaez@scripps.edu.
Scripps Research Institute · USQB3 · USUConn Health · USWashington State University · US
Funding
Chemoproteomic Identification and Therapeutic Validation of Proteins of Metabolic SignificanceRC2DK114785 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SAEZ, ENRIQUE · 2017 to 2021
$8.2MIdentification and Therapeutic Valiation of Adipocyte Serine Hydrolases of MetabR24DK099810 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SAEZ, ENRIQUE · 2013 to 2016
$4.7MRegulation of TH17 Cell Development and Function by the REV-ERBsR01AI116885 · NIAID · SCRIPPS FLORIDA · PI SOLT, LAURA A · 2016 to 2020
$2.1MImpact of Heme Homeostasis on Adipocyte FunctionR01DK121196 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI SAEZ, ENRIQUE · 2019 to 2022
$2.1MMechanisms of PGRMC2 action in female reproductionR21OD016564 · OD · WASHINGTON STATE UNIVERSITY · PI PRU, JAMES K · 2014 to 2015
$432kSeahorse XF96 Extracellular Flux AnalyzerS10OD016357 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI SAEZ, ENRIQUE · 2013 to 2013
$175kNIAID NIH HHS R01 AI116885NIDDK NIH HHS R01 DK121196NIDDK NIH HHS R24 DK099810NIDDK NIH HHS RC2 DK114785NIH HHS R21 OD016564NIH HHS S10 OD016357
Abstract
Haem is an essential prosthetic group of numerous proteins and a central signalling molecule in many physiologic processes
Indexed as
AdipocytesAnimalsHemeHomeostasisHumansIntracellular SpaceMaleMembrane ProteinsMice, Inbred C57BLMice, KnockoutMitochondriaMolecular ChaperonesReceptors, ProgesteroneTranscription, GeneticHemeMembrane ProteinsMolecular ChaperonesPGRMC2 protein, humanPGRMC2 protein, mouseReceptors, Progesterone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.