Evidence map›Paper›PMID 31748738›Full record

ReviewNature reviews. Microbiology2020

Bacterial siderophores in community and host interactions.

Jos Kramer, Özhan Özkaya, Rolf Kümmerli

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 493 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
493citing papers in PubMed, 1 pooled it
58.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

493 citing papers in PubMed, 1 synthesis or guideline pooled it, 934 citations in OpenAlex.

  1. Principles for Rigorous Design and Application of Synthetic Microbial Communities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Structural and Functional Siderophore Remodeling by Enzymatic Delipidation.Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Review
  8. Review
  9. A review of the iron requirements and its determination in commercial poultry.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Molecular characterization of extended-spectrum β-lactamases-producing Escherichia coli isolated from patients with bacteremia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  20. Review

433 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jos Kramer *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-2155-9295
Özhan Özkaya *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0885-4989
Rolf KümmerliDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. rolf.kuemmerli@uzh.ch.ORCID http://orcid.org/0000-0003-4084-6679
University of Zurich · CH

Funding

European Research Council 681295Swiss National Science Foundation 182499
6 · The paper itself

Abstract

Iron is an essential trace element for most organisms. A common way for bacteria to acquire this nutrient is through the secretion of siderophores, which are secondary metabolites that scavenge iron from environmental stocks and deliver it to cells via specific receptors. While there has been tremendous interest in understanding the molecular basis of siderophore synthesis, uptake and regulation, questions about the ecological and evolutionary consequences of siderophore secretion have only recently received increasing attention. In this Review, we outline how eco-evolutionary questions can complement the mechanistic perspective and help to obtain a more integrated view of siderophores. In particular, we explain how secreted diffusible siderophores can affect other community members, leading to cooperative, exploitative and competitive interactions between individuals. These social interactions in turn can spur co-evolutionary arms races between strains and species, lead to ecological dependencies between them and potentially contribute to the formation of stable communities. In brief, this Review shows that siderophores are much more than just iron carriers: they are important mediators of interactions between members of microbial assemblies and the eukaryotic hosts they inhabit.

Indexed as

Microbial InteractionsBacteriaBiological EvolutionIronSelection, GeneticSiderophoresIronSiderophores

Identifiers

PMID31748738
PMCPMC7116523
OpenAlexW2990378266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.