Evidence map›Paper›PMID 31748690›Full record

ArticleMolecular psychiatry2020

A major role for common genetic variation in anxiety disorders.

Kirstin L Purves, Jonathan R I Coleman, Sandra M Meier, Christopher Rayner, Katrina A S Davis, Rosa Cheesman, Marie Bækvad-Hansen, Anders D Børglum, Shing Wan Cho, J Jürgen Deckert and 16 more

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 13 pooled it
50.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 13 syntheses or guidelines pooled it, 454 citations in OpenAlex.

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  10. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2022
    Pooled it
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  13. Genome-wide association study of shared liability to anxiety disorders in Army STARRS.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020
    Pooled it
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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 5 countries.

Kirstin L PurvesKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-8110-5554
Jonathan R I ColemanKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-6759-0944
Sandra M MeierChild and Adolescent Mental Health Centre-Mental Health Services Capital Region, Copenhagen Region, Denmark.
Christopher RaynerKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0003-2950-343X
Katrina A S DavisNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Rosa CheesmanKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-6543-0402
Marie Bækvad-HansenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Anders D BørglumThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.ORCID http://orcid.org/0000-0001-8627-7219
Shing Wan ChoKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
J Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Héléna A GasparKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-5540-2707
Jonas Bybjerg-GrauholmThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.ORCID http://orcid.org/0000-0003-1705-4008
John M HettemaDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Matthew HotopfNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
David HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Christopher HübelKing's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-1267-8287
Carol KanKing's College London; Psychological Medicine; Institute of Psychiatry, Psychology & Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-2511-0682
Andrew M McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Ole MorsPsychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
Preben Bo MortensenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Merete NordentoftThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Kristin K NicodemusCentre for Genomic and Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6165-6471
Manuel MattheisenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Gerome Breen *King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK. gerome.breen@kcl.ac.uk.ORCID http://orcid.org/0000-0003-2053-1792
Thalia C Eley *King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK. thalia.eley@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6458-0700
King's College London · GBAarhus University · DKStatens Serum Institut · DKUniversity of Copenhagen · DKAarhus University Hospital · DKMental Health Services · DKUniversitätsklinikum Würzburg · DEUniversity of Edinburgh · GBVirginia Commonwealth University · USWestern General Hospital · GB

Funding

5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9M
Genome-wide association studies of anxiety spectrum phenotypes: Furthering the PGC Anxiety Disorders Working GroupR01MH113665 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOHN M HETTEMA · 2017 to 2026
$2.6M
Department of HealthMedical Research Council MR/M021475/1NIMH NIH HHS R01 MH113665NIMH NIH HHS U01 MH109514
6 · The paper itself

Abstract

Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyAnxiety DisordersGenetic VariationHumansNeuroticismPolymorphism, Single Nucleotide

Identifiers

PMID31748690
PMCPMC7237282
OpenAlexW2949479576

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.