ArticleScientific reports2019
Seasonal variability does not impact in vitro fertilization success.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between season and pregnancy outcomes in fresh embryo transfer cycles: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Association between ambient temperature exposure and pregnancy outcomes in participants undergoing IVF: a retrospective cohort study.Journal of assisted reproduction and genetics · 2026Article
- Association between meteorological season and embryo quality in the era of morphokinetics.JBRA assisted reproduction · 2025Article
- The association between season and meteorological factors on clinical outcomes after fresh embryo transfer: a cohort study from Central Plains, China.Frontiers in endocrinology · 2025Article
- The impact of seasonal variations on IVF pregnancy outcomes: a retrospective cohort study in Jinan, China.Frontiers in medicine · 2025Article
- Bilateral versus unilateral orchidopexy: IVF/ICSI-ET outcomes.Frontiers in endocrinology · 2024Article
- Embryo transfers performed during daylight savings time led to reduced live birth rates in older patients.Journal of assisted reproduction and genetics · 2023Observational
- Seasonal fluctuation of in vitro fertilization encounters in the United States.Journal of assisted reproduction and genetics · 2023Article
- Season and temperature do not affect cumulative live birth rate and time to live birth inFrontiers in endocrinology · 2023Article
- Influence of climatic conditions in the mesothermal climate area on pregnancies following elective fresh single blastocyst transfer.Journal of assisted reproduction and genetics · 2022Article
- Effects of seasonal variations and meteorological factors on IVF pregnancy outcomes: a cohort study from Henan Province, China.Reproductive biology and endocrinology : RB&E · 2022Article
- Seasonal dynamic of cholecalciferol (D3) and anti-Muellerian hormone (AMH) with impact on ovarian response and IVF/ICSI.Archives of gynecology and obstetrics · 2022Article
- Summer is not associated with higher live birth rates in fresh IVF/ICSI cycles: a population-based nationwide registry study.Human reproduction open · 2022Article
- Endometrial thickness is associated with low birthweight in frozen embryo transfer cycles: A retrospective cohort study of 8,235 singleton newborns.Frontiers in endocrinology · 2022Article
- Change in the Strategy of Embryo Selection with Time-Lapse System Implementation-Impact on Clinical Pregnancy Rates.Journal of clinical medicine · 2021Article
- The effect of seasonality on reproductive outcome of patients undergoing intracytoplasmic sperm injection: A descriptive cross-sectional study.International journal of reproductive biomedicine · 2020Review
- Seasonal variation, temperature, day length, and IVF outcomes from fresh cycles.Journal of assisted reproduction and genetics · 2020Article
- Seasonal Influence on Assisted Reproductive Technology Outcomes: A Retrospective Analysis of 1409 Cycles.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is unknown whether seasonal variation influences the outcome of in vitro fertilization (IVF). Previous studies related to seasonal variation of IVF were all small sample size, and the results were conflicting. We performed a retrospective cohort study evaluating the relationship between seasonal variability and live birth rate in the year of 2014-2017. Patients were grouped into four seasons (Winter (December-February), Spring (March-May), Summer (June-August), and Autumn (September-November)) according to the day of oocyte pick-up (OPU). Multivariate logistic regression analysis was performed to evaluate association between seasonal variation and live birth. Models were adjusted for covariates including temperature, sunshine hour, infertility type, infertility duration, infertility factor and BMI. In total 38,476 women were enrolled, of which 25,097 underwent fresh cycles, 13,379 were frozen embryo transfer. Live birth rates of fresh embryo transfer were 50.36%, 53.14%, 51.94% and 51.33% for spring, summer, autumn and winter, respectively. Clinical pregnancy rate between the calendar months varied between 55.1% and 63.4% in fresh embryo transfer (ET) and between 58.8% and 65.1% in frozen embryo transfer (FET) (P-values 0.073 and 0.220). In the unadjusted model and adjust model, seasonal variation was not associated with live birth. In conclusion, there was no significant difference of seasonal variations in the outcome of IVF with fresh embryo transfer and frozen embryo transfer.
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