ArticleScientific reports2019
Early detection of enamel demineralization by optical coherence tomography.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Tooth Enamel Demineralization: Caries and Erosion from the Viewpoint of Chemistry.Dentistry journal · 2026Review
- Enhancing cementoenamel junction (CEJ) imaging using gold nanorods in optical coherence tomography (OCT).Lasers in medical science · 2025Article
- Evaluation of the effectiveness of different remineralization agents on primary and permanent teeth exposed to acidic liquids: a randomized controlled in vitro study.BMC oral health · 2025Article
- Evaluating the effects of remineralizing agents on initial carious lesions.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2025Article
- Examining enamel-surface demineralization upon exposure to acidic solutions and the remineralization potential of milk and artificial saliva.Odontology · 2025Article
- Comparative analysis of enamel mineral content and surface morphology alterations after bleaching: a study using colorimetric spectrophotometry and scanning electron microscopy.Frontiers in dental medicine · 2025Article
- Validity and Reliability of Intraoral Optical Coherence Tomography and Bitewing Radiography for Detecting Approximal Carious Lesions.Caries research · 2025Article
- Visualization of carious lesions with polarized and depolarized light microscopy.Biomedical optics express · 2024Article
- Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract.Materials (Basel, Switzerland) · 2024Article
- Quantitative Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography.Bioengineering (Basel, Switzerland) · 2023Article
- The preventive/therapeutic effect of COHeliyon · 2023Article
- Spatial analysis of polarimetric images to enhance near-surface sampling sensitivity: feasibility in demineralized teeth and other tissue-like media.Journal of biomedical optics · 2023Article
- Review
- Effect of N-Acetylcysteine on initial Carious Enamel Lesions in primary teeth: an In-vitro study.BMC oral health · 2023Article
- Laboratory evaluation of anti-plaque and remineralization efficacy of sugarless probiotic jelly candy supplemented with natural nano prebiotic additive.Scientific reports · 2023Article
- Repeated Etching Cycles of Resin Infiltration up to Nine Cycles on Demineralized Enamel: Surface Roughness and Esthetic Outcomes-In Vitro Study.Children (Basel, Switzerland) · 2023Article
- Article
- Article
- Oral Cancer Screening by Artificial Intelligence-Oriented Interpretation of Optical Coherence Tomography Images.Radiology research and practice · 2022Review
- The Effects of Three Remineralizing Agents on the Microhardness and Chemical Composition of Demineralized Enamel.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study, a high-resolution optical coherence tomography (OCT) system with the axial and transverse resolutions of 2.0 and 2.7 μm in teeth has been utilized for characterizing the effect of the acidic environment (simulated by phosphoric acid) on the enamel topology. The scattering coefficient and the surface roughness of enamel can be directly derived from the OCT results, enabling a quantitative evaluation of the topology changes with demineralization. The dynamic process induced by the acid application is also recorded and analyzed with OCT, depicting the evolution of the demineralization process on enamel. Notably, the estimated enamel scattering coefficient and surface roughness significantly increase with the application time of acid and the results illustrate that the values of both parameters after demineralization are significantly larger than those obtained before the demineralization, illustrating both parameters could be effective to differentiate the healthy and demineralized teeth and determine the severity. The obtained results unambiguously illustrate that demineralization of the tooth surface can be successfully detected by OCT and further used as an indicator of early-stage cavity formation.
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