Evidence map›Paper›PMID 31748568›Full record

ArticleNature communications2019

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.

Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J W Shimon, Michael R Sawaya, Sofiya Kolusheva, David S Eisenberg and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 40 citations in OpenAlex.

  1. Guanine Crystallization by Particle Attachment.Journal of the American Chemical Society · 2025
    Article
  2. Article
  3. Morphology and Applications of Self-Assembled Peptide Nucleic Acids.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  10. Review
  11. Supramolecular Architectures of Nucleic Acid/Peptide Hybrids.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Vasantha BasavalingappaDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel.ORCID http://orcid.org/0000-0003-3459-5324
Santu BeraDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel.ORCID http://orcid.org/0000-0002-4830-552X
Bin XueCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University, 210093, Nanjing, People's Republic of China.
Ido AzuriDepartment of Materials and Interfaces, Weizmann Institute of Science, 76100, Rehovoth, Israel.
Yiming TangDepartment of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), Fudan University, 200433, Shanghai, People's Republic of China.ORCID http://orcid.org/0000-0002-2976-5547
Kai TaoDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel.ORCID http://orcid.org/0000-0003-3899-5181
Linda J W ShimonDepartment of Chemical Research Support, Weizmann Institute of Science, 76100, Rehovoth, Israel.ORCID http://orcid.org/0000-0002-7861-9247
Michael R SawayaHoward Hughes Medical Institute, UCLA-DOE Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0003-0874-9043
Sofiya KolushevaIlse Katz Institute for Nanotechnology, Ben Gurion University of the Negev, 84105, Beer Sheva, Israel.
David S EisenbergHoward Hughes Medical Institute, UCLA-DOE Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0003-2432-5419
Leeor KronikDepartment of Materials and Interfaces, Weizmann Institute of Science, 76100, Rehovoth, Israel.
Yi CaoCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University, 210093, Nanjing, People's Republic of China.ORCID http://orcid.org/0000-0003-1493-7868
Guanghong WeiDepartment of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), Fudan University, 200433, Shanghai, People's Republic of China.
Ehud GazitDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel. ehudg@post.tau.ac.il.ORCID http://orcid.org/0000-0001-5764-1720
Tel Aviv University · ILWeizmann Institute of Science · ILCollaborative Innovation Center of Advanced Microstructures · CNFudan University · CNHoward Hughes Medical Institute · USBen-Gurion University of the Negev · IL

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
NCRR NIH HHS S10 RR029205NIGMS NIH HHS P30 GM124165
6 · The paper itself

Abstract

The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit their application. Here, we combine the advantages of polyamide materials and the structural patterns inspired by nucleic-acids to generate a mechanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology and photoluminescent properties. The assembly possesses a unique atomic structure, with each guanine head of one molecule hydrogen bonded to the Fmoc carbonyl tail of another molecule, generating a non-planar cyclic quartet arrangement. This structure exhibits an average stiffness of 69.6 ± 6.8 N m

Indexed as

Crystallography, X-RayDNAElastic ModulusFluorenesGuanineMicroscopy, Electron, ScanningModels, MolecularNanostructuresNanotechnologyPeptide Nucleic AcidsDNAFluorenesGuaninePeptide Nucleic Acids

Identifiers

PMID31748568
PMCPMC6868146
OpenAlexW2991103739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.