ArticleScientific reports2019
Compressive Remodeling Alters Fluid Transport Properties of Collagen Networks - Implications for Tumor Growth.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 54 citations in OpenAlex.
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- Modeling tumor transport and growth with poroelastic biopolymer networks.bioRxiv : the preprint server for biology · 2025Article
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- Shear and Compressive Stiffening of Dual-Cross-Linked Alginate Hydrogels with Tunable Viscoelasticity.ACS applied bio materials · 2025Article
- Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing.Nature communications · 2025Article
- Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts.Gels (Basel, Switzerland) · 2024Review
- Associations between Diabetes Mellitus and Selected Cancers.International journal of molecular sciences · 2024Review
- Compressive instabilities enable cell-induced extreme densification patterns in the fibrous extracellular matrix: Discrete model predictions.PLoS computational biology · 2024Article
- Mechanical compression regulates tumor spheroid invasion into a 3D collagen matrix.Physical biology · 2024Article
- Cancer cell response to extrinsic and intrinsic mechanical cue: opportunities for tumor apoptosis strategies.Regenerative biomaterials · 2024Review
- The role and mechanism of compressive stress in tumor.Frontiers in oncology · 2024Review
- Asymmetry of tensile versus compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels.Science advances · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Biomechanical alterations to the tumor microenvironment include accumulation of solid stresses, extracellular matrix (ECM) stiffening and increased fluid pressure in both interstitial and peri-tumoral spaces. The relationship between interstitial fluid pressurization and ECM remodeling in vascularized tumors is well characterized, while earlier biomechanical changes occurring during avascular tumor growth within the peri-tumoral ECM remain poorly understood. Type I collagen, the primary fibrous ECM constituent, bears load in tension while it buckles under compression. We hypothesized that tumor-generated compressive forces cause collagen remodeling via densification which in turn creates a barrier to convective fluid transport and may play a role in tumor progression and malignancy. To better understand this process, we characterized the structure-function relationship of collagen networks under compression both experimentally and computationally. Here we show that growth of epithelial cancers induces compressive remodeling of the ECM, documented in the literature as a TACS-2 phenotype, which represents a localized densification and tangential alignment of peri-tumoral collagen. Such compressive remodeling is caused by the unique features of collagen network mechanics, such as fiber buckling and cross-link rupture, and reduces the overall hydraulic permeability of the matrix.
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