Evidence map›Paper›PMID 31748553›Full record

ArticleNature communications2019

Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus.

Xuming Chen, Filip Sobczak, Yi Chen, Yuanyuan Jiang, Chunqi Qian, Zuneng Lu, Cenk Ayata, Nikos K Logothetis, Xin Yu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 246 citations in OpenAlex.

  1. Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  4. Review
  5. Article
  6. Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  7. Article
  8. High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Xuming ChenResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, 72076, Tuebingen, Germany.
Filip SobczakResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, 72076, Tuebingen, Germany.
Yi ChenResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, 72076, Tuebingen, Germany.
Yuanyuan JiangResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, 72076, Tuebingen, Germany.
Chunqi QianDepartment of Radiology, Michigan State University, East Lansing, 48824, MI, USA.
Zuneng LuDepartment of Neurology, Wuhan University, Renmin Hospital, Wuhan, 430060, China.
Cenk AyataNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, MA, USA.
Nikos K LogothetisDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, 72076, Germany.
Xin YuResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, 72076, Tuebingen, Germany. xyu9@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-9890-5489
Harvard University · USMax Planck Institute for Biological Cybernetics · DEWuhan University · CNMichigan State University · USUniversity of Manchester · GB

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Resting state connectivity: Biophysical basis for and improved fMRI measurementsR01MH111438 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID, ROSEN, BRUCE R · 2016 to 2020
$5.2M
Investigating the Thalamic Regulation of Neuro-Glio-Vascular Restoration Underlying Acute Coma Recovery with Multi-Modal fMRI in a Brainstem Coma Rodent ModelR01NS122904 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2021 to 2025
$3.2M
Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber arrayRF1NS113278 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2019 to 2019
$2.0M
NIMH NIH HHS R01 MH111438NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS122904NINDS NIH HHS RF1 NS113278
6 · The paper itself

Abstract

Extensive in vivo imaging studies investigate the hippocampal neural network function, mainly focusing on the dorsal CA1 region given its optical accessibility. Multi-modality fMRI with simultaneous hippocampal electrophysiological recording reveal broad cortical correlation patterns, but the detailed spatial hippocampal functional map remains lacking given the limited fMRI resolution. In particular, hemodynamic responses linked to specific neural activity are unclear at the single-vessel level across hippocampal vasculature, which hinders the deciphering of the hippocampal malfunction in animal models and the translation to critical neurovascular coupling (NVC) patterns for human fMRI. We simultaneously acquired optogenetically-driven neuronal Ca

Indexed as

Cortical Spreading DepressionEvoked PotentialsNeurovascular CouplingAnimalsArteriolesCalciumCerebral Blood VolumeFunctional NeuroimagingHippocampusMagnetic Resonance ImagingNeuronsOptogeneticsRatsVenulesCalcium

Identifiers

PMID31748553
PMCPMC6868210
OpenAlexW2922355439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.