ArticleScientific reports2019
Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Hydroxy acid conjugation to lipids increases structural and hydrolytic stability.Nature communications · 2026Article
- Membrane curvature enhances oxidation within lipid bilayers in a composition-dependent manner.Biophysical journal · 2026Article
- Article
- Molecular Dynamics Simulation of Passive Diffusion across a Human Breast Cancer Cell Membrane Model. Comparison between Cisplatin and Its Pt(IV) Derivatives.Journal of chemical information and modeling · 2026Article
- Membrane curvature enhances oxidation within lipid bilayers in a composition-dependent manner.bioRxiv : the preprint server for biology · 2026Article
- Targeting the Weak Spot: Preferential Disruption of Bacterial Poles by Janus Nanoparticles.Nano letters · 2024Article
- HiViPore: a highly viable in-flow compression for a one-step cell mechanoporation in microfluidics to induce a free delivery of nano- macro-cargoes.Journal of nanobiotechnology · 2024Article
- Antidepressants enter cells, organelles, and membranes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Interaction of Quercetin, Cyanidin, and TheirMembranes · 2023Article
- Defining permeability of curved membranes in molecular dynamics simulations.Biophysical journal · 2023Article
- Effect of Cisplatin and Its Cationic Analogues in the Phase Behavior and Permeability of Model Lipid Bilayers.Molecular pharmaceutics · 2023Article
- The impact of physiologically relevant temperatures on physical properties of thylakoid membranes: a molecular dynamics study.Photosynthetica · 2023Article
- The role of extended synaptotagmin at membrane contact sites in cancer research.Frontiers in cell and developmental biology · 2023Review
- Surface functionalization of graphene nanosheet with poly (L-histidine) and its application in drug delivery: covalent vs non-covalent approaches.Scientific reports · 2022Article
- Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission.Biochimica et biophysica acta. Biomembranes · 2022Article
- Molecular Dynamics Simulations of Curved Lipid Membranes.International journal of molecular sciences · 2022Review
- Experimental Investigations on the Conductance of Lipid Membranes under Differential Hydrostatic Pressure.Membranes · 2022Article
- Interaction ofInternational journal of environmental research and public health · 2022Article
- Shape transformations of red blood cells in the capillary and their possible connections to oxygen transportation.Journal of biological physics · 2022Article
- Study of Resveratrol's Interaction with Planar Lipid Models: Insights into Its Location in Lipid Bilayers.Membranes · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work the permeability of a model asymmetric plasma membrane, for ions, water and the anti-cancer drugs cisplatin and gemcitabine is studied by means of all-atom molecular dynamics simulations. It is shown for the first time that permeability of the highly curved membrane increases from one to three orders of magnitude upon membrane bending depending on the compound and the sign of curvature. Our results suggest that the membrane curvature could be an important factor of drug translocation through the membrane.
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