Evidence map›Paper›PMID 31748528›Full record

ArticleScientific reports2019

Area of residual tumor (ART) can predict prognosis after post neoadjuvant therapy resection for pancreatic ductal adenocarcinoma.

Satoshi Okubo, Motohiro Kojima, Yoko Matsuda, Masayoshi Hioki, Yasuhiro Shimizu, Hirochika Toyama, Soichiro Morinaga, Naoto Gotohda, Katsuhiko Uesaka, Genichiro Ishii and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Satoshi OkuboDivision of pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan.
Motohiro KojimaDivision of pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan. mokojima@east.ncc.go.jp.
Yoko MatsudaDepartment of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Sakae-cho, Itabashi-ku, Tokyo, Japan.
Masayoshi HiokiDepartment of Gastroenterological Surgery, Fukuyama City Hospital, Okayama, Japan.
Yasuhiro ShimizuDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Hirochika ToyamaDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan.
Soichiro MorinagaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
Naoto GotohdaDepartment of Hepatobiliary and Pancreatic surgery, National Cancer Center Hospital East, Chiba, Japan.
Katsuhiko UesakaDivision of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Genichiro IshiiDivision of pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan.
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9092-2265
Shinichiro TakahashiDepartment of Hepatobiliary and Pancreatic surgery, National Cancer Center Hospital East, Chiba, Japan.
National Cancer Center Hospital East · JPAichi Cancer Center · JPFukuyama City Hospital · JPHarvard University · USKanagawa Prefectural Hospital Organization · JPKobe University · JPShizuoka Cancer Center · JPTokyo Metropolitan Geriatric Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of patients with pancreatic ductal adenocarcinoma (PDAC) have undergone resection after neoadjuvant therapy (NAT). We have reported Area of Residual Tumor (ART) as a useful pathological assessment method to predict patient outcomes after post NAT resection in various cancer types. The aim of this study was to assess the prognostic performance of ART in PDAC resected after NAT. Sixty-three patients with PDAC after post NAT resection were analyzed. The viable residual tumor area was outlined and the measurement of ART was performed using morphometric software. The results were compared with those of the College of American Pathologist (CAP) regression grading. Of 63 cases, 39 (62%) patients received chemoradiation therapy and 24 (38%) received chemotherapy only. The median value of ART was 163 mm

Indexed as

AdenocarcinomaAdultAgedCarcinoma, Pancreatic DuctalChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm, ResidualPancreatic NeoplasmsPancreaticoduodenectomy

Identifiers

PMID31748528
PMCPMC6868132
OpenAlexW2990762280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.