ArticleNature communications2019
Characterization of antibiotic resistance genes in the species of the rumen microbiota.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Dietary baicalin supplementation enhances growth performance in fattening Hu sheep via dual modulation of immunity and gastrointestinal microbiome-metabolic crosstalk.Journal of animal science and biotechnology · 2026Article
- Metagenomic analysis of antimicrobial resistance, virulence, and mobile genetic elements in the gut microbiota of Caprinae species.Communications biology · 2026Article
- Gut microbiota and resistome profiles of Swiss expatriates in Africa revealed by Nanopore metagenomics.Scientific reports · 2026Article
- IME_Rho_tet, a novel family of putative integrative mobilizable elements spreading tetracycline resistance genesMicrobial genomics · 2026Article
- Animal type outweighs growth stage in shaping the active antibiotic resistome in livestock manure.Frontiers in microbiology · 2026Article
- The resistome bridge between livestock and workers: novel frameworks for early detection and monitoring of antimicrobial resistance.Frontiers in public health · 2026Review
- PLGA nanoparticles loaded with recombinant antimicrobial protein PIP significantly improves the survival state and pathological damage caused by ETEC O8-induced sepsis in mice.Frontiers in veterinary science · 2026Article
- Sodium Butyrate Supplementation in Whole Milk Modulates the Gastrointestinal Microbiota Without Altering the Resistome and Virulome in Preweaned Calves.Microorganisms · 2025Article
- Antioxidant and Anti-Inflammatory Activities ofNutrients · 2025Article
- Genomic characterization of antimicrobial resistance and mobile genetic elements in swine gut bacteria isolated from a Canadian research farm.Animal microbiome · 2025Article
- Metagenomic analysis revealed the distribution of antibiotic resistance genes of Awang sheep (Frontiers in microbiology · 2025Article
- Feeding systems influence the rumen resistome in yaks by changing the microbiome.Frontiers in microbiology · 2025Article
- A metagenomic catalogue of the ruminant gut archaeome.Nature communications · 2024Article
- Seasonal stability of the rumen microbiome contributes to the adaptation patterns to extreme environmental conditions in grazing yak and cattle.BMC biology · 2024Article
- Exploration of mobile genetic elements in the ruminal microbiome of Nellore cattle.Scientific reports · 2024Article
- Accessory genes define species-specific routes to antibiotic resistance.Life science alliance · 2024Article
- Effects ofApplied and environmental microbiology · 2024Article
- Fecal microbial gene transfer contributes to the high-grain diet-induced augmentation of aminoglycoside resistance in dairy cattle.mSystems · 2024Article
- Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids.Microbiome · 2024Article
- Prospects and Challenges of Bacteriophage Substitution for Antibiotics in Livestock and Poultry Production.Biology · 2024Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections caused by multidrug resistant bacteria represent a therapeutic challenge both in clinical settings and in livestock production, but the prevalence of antibiotic resistance genes among the species of bacteria that colonize the gastrointestinal tract of ruminants is not well characterized. Here, we investigate the resistome of 435 ruminal microbial genomes in silico and confirm representative phenotypes in vitro. We find a high abundance of genes encoding tetracycline resistance and evidence that the tet(W) gene is under positive selective pressure. Our findings reveal that tet(W) is located in a novel integrative and conjugative element in several ruminal bacterial genomes. Analyses of rumen microbial metatranscriptomes confirm the expression of the most abundant antibiotic resistance genes. Our data provide insight into antibiotic resistange gene profiles of the main species of ruminal bacteria and reveal the potential role of mobile genetic elements in shaping the resistome of the rumen microbiome, with implications for human and animal health.
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