ArticleNature communications2019
In vivo clonal expansion and phenotypes of hypocretin-specific CD4
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1.Scientific reports · 2022Trial
- Immunocyte phenotypes underlying the causal autoimmune features in narcolepsy type 1.Journal of thoracic disease · 2026Article
- Increased Numbers of CD4Annals of neurology · 2026Article
- Cytokines in narcolepsy type 1: pathogenic relevance, biomarker potential, and future directions.Frontiers in neurology · 2026Review
- HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- CD4-Positive T-Cell Responses to MOG Peptides in MOG Antibody-Associated Disease.International journal of molecular sciences · 2025Article
- Computational Immunogenetic Analysis of Botulinum Toxin A Immunogenicity and HLA Gene Haplotypes: New Insights.Toxins · 2025Article
- The Future of TCR-like Antibodies in Diagnosis and Potential Application Targets.Current molecular medicine · 2025Review
- TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV.Frontiers in immunology · 2025Article
- The immunopathogenesis of narcolepsy type 1.Nature reviews. Immunology · 2024Review
- Advances in Adjuvanted Influenza Vaccines.Vaccines · 2023Review
- Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.Nature communications · 2023Article
- Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis.Frontiers in genetics · 2023Article
- Reactogenic sleepiness after COVID-19 vaccination. A hypothesis involving orexinergic system linked to inflammatory signals.Sleep medicine · 2022Review
- Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation.Seminars in immunopathology · 2022Review
- Characterization of T cell receptors reactive to HCRTProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles.Cell reports · 2022Article
- Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.Genome medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 6 institutions in 4 countries.
Wei JiangDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA. wjiang6@stanford.edu.ORCID http://orcid.org/0000-0001-7883-8418
James R BirtleyDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.ORCID http://orcid.org/0000-0002-8159-4060
Shu-Chen HungDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA.
Weiqi WangHuman Immune Monitoring Center, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4936-0977
Shin-Heng ChiouInstitute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Claudia MacaubasDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA.
Birgitte KornumDanish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, 2600, Glostrup, Denmark.
Lu TianDepartment of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Huang HuangInstitute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-8377-4823
Lital AdlerDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA.
Grant WeaverDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.ORCID http://orcid.org/0000-0003-1151-2944
Liying LuDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
Alexandra Ilstad-MinnihanDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA.
Sriram SomasundaramDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-7522-914X
Sashi AyyangarDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA.
Mark M DavisStanford Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-6868-657X
Lawrence J SternDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.ORCID http://orcid.org/0000-0001-9870-8557
Elizabeth D MellinsDepartment of Pediatrics-Human Gene Therapy, Stanford University School of medicine, Stanford, CA, 94305, USA. mellins@stanford.edu.ORCID http://orcid.org/0000-0003-2577-139X
Stanford University · USUniversity of Massachusetts Chan Medical School · USStanford Medicine · USHoward Hughes Medical Institute · USRigshospitalet · DKWeizmann Institute of Science · IL
Funding
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0MMOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MStanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1TR000093 · NCATS · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2012 to 2013
$6.5MStructure and Function of MHC ProteinsR37AI038996 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 2008 to 2017
$4.1MStructure and Function of Class II MHC ProteinsR01AI038996 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J · 1996 to 2006
$1.6MStructure and Function of Class II MHC ProteinsR56AI038996 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J · 2007 to 2007
$324kNCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR003142NIAID NIH HHS R01 AI038996NIAID NIH HHS R37 AI038996NIAID NIH HHS R56 AI038996NIAID NIH HHS T32 AI007290
Abstract
Individuals with narcolepsy suffer from abnormal sleep patterns due to loss of neurons that uniquely supply hypocretin (HCRT). Previous studies found associations of narcolepsy with the human leukocyte antigen (HLA)-DQ6 allele and T-cell receptor α (TRA) J24 gene segment and also suggested that in vitro-stimulated T cells can target HCRT. Here, we present evidence of in vivo expansion of DQ6-HCRT tetramer
Indexed as
AnimalsAutoimmunityCase-Control StudiesCD4-Positive T-LymphocytesCell ProliferationCrystallography, X-RayDrosophilaHLA-DQ AntigensHumansImmunoglobulin Joining RegionNarcolepsyOrexinsPeripheral TolerancePhenotypeReceptors, Antigen, T-Cell, alpha-betaHCRT protein, humanHLA-DQ6 antigenHLA-DQ AntigensImmunoglobulin Joining RegionOrexinsReceptors, Antigen, T-Cell, alpha-beta
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.