ReviewEuropean respiratory review : an official journal of the European Respiratory Society2019
Lung clearance index: assessment and utility in children with asthma.
Review in European respiratory review : an official journal of the European Respiratory Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Visualization of childhood allergic diseases based on VOSviewer and CiteSpace.Frontiers in medicine · 2025Pooled it
- The silent zone of paediatric asthma: integrating small airway dysfunction assessment into clinical practice.EClinicalMedicine · 2026Review
- Quantitative analysis of lung function and airway remodeling using ventilation/perfusion single photon emission tomography/computed tomography and HRCT in patients with chronic obstructive pulmonary disease and asthma.Annals of nuclear medicine · 2023Article
- Peripheral airways involvement in children with asthma exacerbation.The clinical respiratory journal · 2022Article
- Ventilation heterogeneity in children with severe asthma.European journal of pediatrics · 2021Observational
- Multiple breath washout: measuring early manifestations of lung pathology.Breathe (Sheffield, England) · 2021Article
- The lower respiratory airway wall in children in health and disease.ERJ open research · 2021Review
- Pulmonary Function Testing in the Coronavirus Disease Era: Lessons and Opportunities.Pediatric allergy, immunology, and pulmonology · 2021Article
- Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls.Frontiers in immunology · 2021Article
- Children with uncontrolled asthma and significant reversibility might show hypoxaemia.European journal of pediatrics · 2020Observational
- Clinical and lung function outcomes in a cohort of children with severe asthma.BMC pulmonary medicine · 2020Article
- Comparative Analysis of Clinical Parameters and Sputum Biomarkers in Establishing the Relevance of Filamentous Fungi in Cystic Fibrosis.Frontiers in cellular and infection microbiology · 2020Article
- Pulmonary Function Testing in Asthmatic Children. Tests to Assess Outpatients During the Covid-19 Pandemic.Frontiers in pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that ventilation heterogeneity and small airway disease are significant factors in asthma, with evidence suggesting that the small airways are involved from an early stage in childhood asthma. Spirometry is commonly used to monitor lung function in asthmatics; however, it is not sensitive to small airway disease. There has been renewed interest in multibreath washout (MBW) tests, with recognition of the lung clearance index (LCI) as a global index of abnormality in gas mixing of the lungs that therefore also reflects small airway disease. This review summarises the technical and practical aspects of the MBW/LCI in children, and the differences between commercially available equipment. Children with severe asthma are more likely to have an abnormal LCI, whereas most children with mild-to-moderate asthma have an LCI within the normal range, but slightly higher than age-matched healthy controls. Monitoring children with asthma with MBW alongside standard spirometry may provide useful additional information.
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Registered trials
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