Evidence map›Paper›PMID 31748386›Full record

ArticleJournal of virology2020

Cytoplasmic Parvovirus Capsids Recruit Importin Beta for Nuclear Delivery.

Elina Mäntylä, Vesa Aho, Michael Kann, Maija Vihinen-Ranta

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Nuclear entry and egress of parvoviruses.Molecular microbiology · 2022
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Elina MäntyläBioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Vesa AhoDepartment of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland.
Michael KannDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Maija Vihinen-RantaDepartment of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland maija.vihinen-rantaC@jyu.fi.ORCID 0000-0003-0959-1153
University of Jyväskylä · FISahlgrenska University Hospital · SETampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family or the direct attachment of the capsid to the nuclear pore complex leading to the local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and

Indexed as

Active Transport, Cell Nucleusalpha KaryopherinsAnimalsbeta KaryopherinsCapsidCapsid ProteinsCell LineCell NucleusCytoplasmCytosolKaryopherinsNuclear EnvelopeNuclear PoreParvoviridae InfectionsParvovirusVirus Internalizationalpha Karyopherinsbeta KaryopherinsCapsid ProteinsKaryopherinscytoplasmimportin βinteractionnucleoplasmparvovirus capsid

Identifiers

PMID31748386
PMCPMC6997771
OpenAlexW2990288490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.