ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Pattern Separation and Source Memory Engage Distinct Hippocampal and Neocortical Regions during Retrieval.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03860857 (The BEACoN Study- Biomarker Exploration in Aging, Cognition and Neurodegeneration), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The BEACoN Study- Biomarker Exploration in Aging, Cognition and Neurodegeneration
Who cites it
41 citing papers in PubMed.
- Virtual reality video game improves high-fidelity memory in older adults.Scientific reports · 2021Trial
- Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation.Neural plasticity · 2020Trial
- Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High-Resolution Whole-Brain fMRI Investigation.Hippocampus · 2026Article
- The Spatial Similarity Task: A cross-species approach to spatial memory.Behavior research methods · 2026Article
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making.Human brain mapping · 2026Article
- N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury.International journal of molecular sciences · 2026Article
- Greater Interference From Multiple Exposures During Memory Retrieval Drives More Memorable and Forgettable Experiences.Hippocampus · 2026Article
- Impaired consolidation of spatial memory during sleep in patients with leucine-rich glioma-inactivated 1-associated limbic encephalitis.Brain communications · 2026Article
- Hippocampal formation-cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task.Frontiers in aging neuroscience · 2026Article
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Contextual Influence on Pattern Separation During Encoding.NeuroSci · 2025Article
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
- The need for details for object discrimination and mnemonic discrimination.Frontiers in cognition · 2025Article
- Pattern separation involves regions beyond the hippocampus in non-demented elderly individuals: A 7T object lure task fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Turns around periodic spatial boundaries facilitate increasing event segmentation over time.Royal Society open science · 2024Article
- Cross-cultural comparison of the neural correlates of true and false memory retrieval.Memory (Hove, England) · 2024Article
- Neural basis of false recognition in Alzheimer's disease and dementia with lewy bodies.Scientific reports · 2024Article
- Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hippocampal Functional Connectivity and Cognitive Stability in Parasellar Meningiomas (Studied by the "Virtually Implanted Electrode" Method).Sovremennye tekhnologii v meditsine · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Detailed representations of past events rely on the ability to form associations between items and their contextual features (i.e., source memory), as well as the ability to distinctly represent a new event from a similar one stored in memory (i.e., pattern separation). These processes are both known to engage the hippocampus, although whether they share similar mechanisms remains unclear. It is also unknown if, and in which region(s), activity related to these processes overlaps and/or interacts. Here, we used high-resolution fMRI to examine the contributions of hippocampal subfields and neocortical areas to pattern separation and source memory with an experimental paradigm that concurrently tested both. During encoding, male and female human subjects incidentally studied items in one of four quadrants on the screen. During test, they viewed repeated items (targets), similar items (lures), and new items (foils) and were asked to indicate whether each item was old, similar, or new. Following each item judgment, subjects were asked to indicate the quadrant in which the original stimulus was presented. Thus, each lure trial had a lure discrimination component (taxing pattern separation) and a location judgment (source memory). We found two main response profiles: (1) pattern separation-related signals in DG/CA3 and perirhinal cortex and (2) source memory signals in posterior CA1, parahippocampal cortex, and angular gyrus. Whole-brain voxelwise analysis revealed that activity related to lure discrimination and source memory was largely nonoverlapping. These findings suggest that distinct processes underlie the retrieval of pattern separated item representations and recollection of source information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.