Evidence map›Paper›PMID 31748376›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity.

Gabriel E Vázquez-Vélez, Kristyn A Gonzales, Jean-Pierre Revelli, Carolyn J Adamski, Fatemeh Alavi Naini, Aleksandar Bajić, Evelyn Craigen, Ronald Richman, Sabrina M Heman-Ackah, Matthew J A Wood and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  5. Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  10. A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn ("line 61") Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  11. Review
  12. Article
  13. DCLK1 autoinhibition and activation in tumorigenesis.Innovation (Cambridge (Mass.)) · 2022
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Gabriel E Vázquez-VélezJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Kristyn A GonzalesJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Jean-Pierre RevelliJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Carolyn J AdamskiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Fatemeh Alavi NainiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Aleksandar BajićJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.ORCID 0000-0002-1255-9835
Evelyn CraigenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Ronald RichmanJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Sabrina M Heman-AckahDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.
Matthew J A WoodDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.
Maxime W C RousseauxJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.ORCID 0000-0002-2737-6193
Huda Y ZoghbiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, hzoghbi@bcm.edu.ORCID 0000-0002-0700-3349
Neurological Research Institute · USHoward Hughes Medical Institute · USUniversity of Oxford · GB

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, NELSON, DAVID LOREN · 2014 to 2019
$7.8M
Tecan EVO GenePaint robotS10OD016167 · OD · BAYLOR COLLEGE OF MEDICINE · PI LJUNGBERG, CECILIA · 2013 to 2013
$215k
Howard Hughes Medical InstituteNICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIH HHS S10 OD016167
6 · The paper itself

Abstract

α-Synuclein (α-Syn) accumulation is a pathological hallmark of Parkinson's disease. Duplications and triplications of

Indexed as

alpha-SynucleinAnimalsDoublecortin-Like KinasesGene Knockdown TechniquesHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLNeuronsParkinson DiseaseProtein Serine-Threonine Kinasesalpha-SynucleinDCLK1 protein, humanDclk1 protein, mouseDoublecortin-Like KinasesIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesDCLK1disease modelsprotein levelsα-synuclein

Identifiers

PMID31748376
PMCPMC6948939
OpenAlexW2991418293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.