Evidence map›Paper›PMID 31748324›Full record

ArticleJournal of clinical microbiology2020

Evaluation of Calcium-Enhanced Media for Colistin Susceptibility Testing by Gradient Agar Diffusion and Broth Microdilution.

Daniel A Green, Nenad Macesic, Anne-Catrin Uhlemann, Mabel Lopez, Stephania Stump, Susan Whittier, Audrey N Schuetz, Patricia J Simner, Romney M Humphries

Open access · greenAbstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Daniel A GreenDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA dag2149@cumc.columbia.edu.ORCID 0000-0002-2394-1319
Nenad MacesicDivision of Infectious Diseases, Columbia University Medical Irving Medical Center, New York, New York, USA.
Anne-Catrin UhlemannDivision of Infectious Diseases, Columbia University Medical Irving Medical Center, New York, New York, USA.
Mabel LopezClinical Microbiology Laboratory, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
Stephania StumpDivision of Infectious Diseases, Columbia University Medical Irving Medical Center, New York, New York, USA.
Susan WhittierDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Audrey N SchuetzDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Patricia J SimnerDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Romney M HumphriesAccelerate Diagnostics, Tucson, Arizona, USA.
Columbia University Irving Medical Center · USNewYork–Presbyterian Hospital · USJohns Hopkins University · USMayo Clinic · USUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the increasing reliance on polymyxin antibiotics (polymyxin B and colistin) for treatment of multidrug-resistant Gram-negative infections, many clinical laboratories are unable to perform susceptibility testing due to the lack of accurate and reliable methods. Although gradient agar diffusion is commonly performed for other antimicrobials, its use for polymyxins is discouraged due to poor performance characteristics. Performing gradient agar diffusion with calcium enhancement of susceptibility testing media has been shown to improve the identification of polymyxin-resistant isolates with plasmid-mediated resistance (

Indexed as

AgarAnti-Bacterial AgentsCalciumColistinCulture MediaDisk Diffusion Antimicrobial TestsDrug Resistance, Multiple, BacterialEnterobacteriaceaeGram-Negative BacteriaGram-Negative Bacterial InfectionsHumansPseudomonas aeruginosaAgarAnti-Bacterial AgentsCalciumColistinCulture Mediaantimicrobial resistanceantimicrobial susceptibility testingcolistinetestgradient agar diffusionGram-negative bacteriamultidrug resistancepolymyxins

Identifiers

PMID31748324
PMCPMC6989058
OpenAlexW2990529131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.