Evidence map›Paper›PMID 31748289›Full record

ArticleBMJ open2019

Characteristics and short-term outcomes of young women with acute myocardial infarction in Malaysia: a retrospective analysis from the Malaysian National Cardiovascular Database registry.

Padmaa Venkatason, Yong Z Zubairi, Nur Lisa Zaharan, Wan Azman Wan Ahmad, Muhammad Imran Hafidz, Muhammad Dzafir Ismail, Mohd Firdaus Hadi, Norashikin Md Sari, Ahmad Syadi Mahmood Zuhdi

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In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Padmaa VenkatasonDepartment of Medicine, University of Malaya Faculty of Medicine, Kuala Lumpur, Malaysia.
Yong Z ZubairiFoundation Studies in Science, Universiti Malaya, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Nur Lisa ZaharanDepartment of Pharmacology, University of Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Wan Azman Wan AhmadCardiology Unit, Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Muhammad Imran HafidzCardiology Unit, Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Muhammad Dzafir IsmailCardiology Unit, Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Mohd Firdaus HadiCardiology Unit, Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Norashikin Md SariCardiology Unit, Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Ahmad Syadi Mahmood ZuhdiCardiology Unit, Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia syadizuhdi@yahoo.co.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveYoung women form a minority but an important group of patients with acute myocardial infarction (MI) as it can potentially cause devastating physical and socioeconomic impact. This study was aimed to investigate the characteristics and outcomes of young women with MI in Malaysia.

designThis is a retrospective analysis of women with ST-elevation MI (STEMI) and non-STEMI (NSTEMI) from 18 hospitals across Malaysia using the Malaysian National Cardiovascular Database registry-acute coronary syndrome (NCVD-ACS).

participantsWomen patients diagnosed with acute MI from year 2006 to 2013 were identified and divided into young (age ≤ 45, n=292) and older women (age >45, n=5580). PRIMARY OUTCOME MEASURE: Comparison of demographics, clinical characteristics and in-hospital management was performed between young and older women. In-hospital and 30-day all-cause mortality were examined.

resultsYoung women (mean age 39±4.68) made up 5% of women with MI and were predominantly of Malay ethnicities (53.8%). They have a higher tendency to present as STEMI compared with older women. Young women have significantly higher rates of family history of premature coronary artery disease (CAD) (20.5% vs 7.8% p<0.0001). The prevalence of risk factors, such as hypertension, diabetes and dyslipidaemia was high in both groups. The primary reperfusion strategy was thrombolysis with no significant differences observed in the choice of intervention for both groups. Other than aspirin, rates of prescriptions for evidence-based medications were similar with >80% prescribed statins and aspirin. The all-cause mortality rates of young women were lower for both in-hospital and 30 days, especially in those with STEMI with adjusted mortality ratio to the older group, was 1:9.84.

conclusionYoung women with MI were over-represented by Malays and those with a family history of premature CAD. Preventive measures are needed to reduce cardiovascular risks in young women. Although in-hospital management was similar, short-term mortality outcomes favoured young compared with older women.

Indexed as

Patient Outcome AssessmentAcute DiseaseAdultDatabases, FactualFemaleHospital MortalityHumansLength of StayMalaysiaMyocardial InfarctionProspective StudiesRegistriesRetrospective StudiesRisk Factorscoronary syndromemortalitymyocardial infarctionpre-menopausalyoung

Identifiers

PMID31748289
PMCPMC6886979

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.