ArticleProceedings of the National Academy of Sciences of the United States of America2019
Contribution of proteasome-catalyzed peptide
Open access · hybridAbstract readMulticenter Study
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Molecular basis for selection and inhibition of HIV-1 escape virus by T cells and KIR2DL2Nature communications · 2025Article
- Proteasome-derived peptides: separating the trash from the recycling.Trends in biochemical sciences · 2025Review
- Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines.Nature communications · 2024Article
- Crucial Parameters for Immunopeptidome Characterization: A Systematic Evaluation.International journal of molecular sciences · 2024Article
- Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing.Nature communications · 2024Article
- MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer.Nature communications · 2024Article
- Non-mutational neoantigens in disease.Nature immunology · 2024Review
- Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response.Nature immunology · 2023Article
- What Can Ribo-Seq, Immunopeptidomics, and Proteomics Tell Us About the Noncanonical Proteome?Molecular & cellular proteomics : MCP · 2023Article
- What can Ribo-seq and proteomics tell us about the non-canonical proteome?bioRxiv : the preprint server for biology · 2023Article
- InvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides.Scientific data · 2023Article
- A Novel Proteogenomic Integration Strategy Expands the Breadth of Neo-Epitope Sources.Cancers · 2022Article
- Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection.Journal of virology · 2022Article
- Article
- Identification of tumor antigens with immunopeptidomics.Nature biotechnology · 2022Review
- ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways.Frontiers in pharmacology · 2022Article
- HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes.Frontiers in immunology · 2022Article
- Mechanistic diversity in MHC class I antigen recognition.The Biochemical journal · 2021Review
- Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise.Proteomics · 2021Review
- Noncontiguous T cell epitopes in autoimmune diabetes: From mice to men and back again.The Journal of biological chemistry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 3 countries.
Wayne PaesNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom; wayne.paes@ndm.ox.ac.uk nicola.ternette@ndm.ox.ac.uk persephone.borrow@ndm.ox.ac.uk.
German LeonovYork Cross-Disciplinary Centre for Systems Analysis, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-6763-5903
Thomas PartridgeNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.
Takayuki ChikataCentre for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.
Hayato MurakoshiCentre for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.
Anna FrangouBig Data Institute, University of Oxford, Oxford OX3 7LF, United Kingdom.
Simon BrackenridgeNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.
Annalisa NicastriNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Andrew G SmithDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Gerald H LearnDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-0434-7733
Yingying LiDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Robert ParkerNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Shinichi OkaCentre for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.
Pierre PellegrinoCentre for Sexual Health and HIV Research, University College London, London WC1E 6JB, United Kingdom.
Ian WilliamsCentre for Sexual Health and HIV Research, University College London, London WC1E 6JB, United Kingdom.
Barton F HaynesDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710.
Andrew J McMichaelNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.
George M ShawDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Beatrice H HahnDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Masafumi TakiguchiCentre for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.
Nicola TernetteNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom; wayne.paes@ndm.ox.ac.uk nicola.ternette@ndm.ox.ac.uk persephone.borrow@ndm.ox.ac.uk.
Persephone BorrowNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom; wayne.paes@ndm.ox.ac.uk nicola.ternette@ndm.ox.ac.uk persephone.borrow@ndm.ox.ac.uk.ORCID 0000-0002-3877-9780
University of Oxford · GBUniversity of Pennsylvania · USKumamoto University · JPUniversity College London · GBDuke University · USNational Center for Global Health and Medicine · JPOpen Data Institute · GBUniversity of York · GB
Funding
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI KEPLER, THOMAS B · 2012 to 2018
$204.7MNonhuman primate studies for development of a prototype HIV vaccine that induces broadly neutralizing antibodiesUM1AI144371 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2019 to 2025
$190.4MVirus and Antibody Gene Sequencing CoreP01AI131251 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Kevin Wiehe · 2017 to 2026
$40.7MTargeting 5' leader-encoded defective ribosomal products for HIV T cell vaccinesR01AI118549 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHAW, GEORGE M · 2016 to 2020
$3.6MMedical Research Council G0902418Medical Research Council MC_UU_12009Medical Research Council MC_UU_12025Medical Research Council MR/K012037Medical Research Council MR/K012037/1Medical Research Council MR/M00919X/1NIAID NIH HHS P01 AI131251NIAID NIH HHS R01 AI118549NIAID NIH HHS UM1 AI100645NIAID NIH HHS UM1 AI144371Wellcome TrustWellcome Trust 097813/Z/11/B#
Abstract
Peptides generated by proteasome-catalyzed splicing of noncontiguous amino acid sequences have been shown to constitute a source of nontemplated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8
Indexed as
AIDS VaccinesAntigens, ViralCD8-Positive T-LymphocytesCell LineCohort StudiesCross-PrimingCross ReactionsDatasets as TopicEpitopes, T-LymphocyteHistocompatibility Antigens Class IHIV-1HIV InfectionsHumansImmune EvasionPeptidesProteasome Endopeptidase ComplexAIDS VaccinesAntigens, ViralEpitopes, T-LymphocyteHistocompatibility Antigens Class IPeptidesProteasome Endopeptidase ComplexRNA, ViralViral Proteinshuman immunodeficiency virusimmunopeptidomepeptide splicingproteasomeT cell epitope
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.